Nitrazepam (Psy and mixed indications) updated on 02-10-2025

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17864
R75434		 Eros, 2002 Cleft lip /- palate during pregnancy (anytime or not specified) excluded case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Yes (with psychiatric (ATD and/or psychotropics) medications) Matched 1.00 [0.10;10.60]
excluded (exposition period) 		1/-   -/- - -
ref
S15359
R63183		 Czeizel, 1987 Isolated cleft lip and/or cleft palate 1st trimester case control unexposed (general population or NOS) Adjustment: No BZD Coexposure: Not specified Matched 5.02 [0.24;104.70] C 2/2   628/1,258 630 2
ref
Total 1 studies 5.02 [0.24;104.70] 630 2
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Czeizel, 1987Czeizel, 1987 5.02[0.24; 104.70]63020%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: moderateROB mesure: unclearROB reporting: moderate0.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 5.02[0.24; 104.70]6302 -NACzeizel, 1987 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.02[0.24; 104.70]6302 -NACzeizel, 1987 1 Tags Adjustment   - No  - No 5.02[0.24; 104.70]6302 -NACzeizel, 1987 1 BZD Coexposure   - Not specified  - Not specified 5.02[0.24; 104.70]6302 -NACzeizel, 1987 1 MatchedMatched 5.02[0.24; 104.70]6302 -NACzeizel, 1987 1 All studiesAll studies 5.02[0.24; 104.70]6302 -NACzeizel, 1987 10.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.02[0.24; 104.70]6302 -NACzeizel, 1987 10.510.01.0