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Hydroxychloroquine (Indication Antiphospholipid Syndrom)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Ye, 2017 Elsenity, 2022
2
0.39
[
0.03
; 4.81]
1
149
not evaluable
Growth parameters and prematurity
Small for gestational age (weight)
Sciascia, 2016 Ye, 2017 Gerde, 2021
3
0.42
[
0.18
; 0.99]
33
216
not evaluable
Preterm (< 37 weeks)
Sciascia, 2016 Ye, 2017
2
0.45
[
0.09
; 2.11]
56
146
not evaluable
Low birth weight (< 2500g)
Ye, 2017
1
0.42
[
0.22
; 0.83]
47
112
not evaluable
Very preterm (28 to 32 weeks)
Mekinian, 2015
1
0.68
[
0.15
; 3.01]
8
35
not evaluable
Maternal consequences
Preeclampsia
Sciascia, 2016 Ye, 2017 Latino, 2020 Gerde, 2021
4
0.32
[
0.14
; 0.70]
46
241
not evaluable
Caesarean
Sciascia, 2016 Elsenity, 2022
2
0.50
[
0.29
; 0.86]
66
82
not evaluable
Abruptio placentae (retroplacental hematoma)
Sciascia, 2016
1
0.24
[
0.01
; 4.81]
3
34
not evaluable
Gestational diabetes
Ye, 2017
1
0.98
[
0.46
; 2.09]
30
126
not evaluable
Maternal consequences (as a whole)
Ruffatti, 2018
1
0.32
[
0.14
; 0.72]
35
94
not evaluable
Neonatal disorders
Low Apgar score (< 7) (at 5 min)
Elsenity, 2022
1
0.38
[
0.19
; 0.75]
22
33
not evaluable
Neonatal death (< 28 days of life)
Elsenity, 2022
1
0.50
[
0.12
; 2.05]
7
33
not evaluable
Neonatal disorders (as a whole)
Mekinian, 2015
1
0.44
[
0.07
; 2.88]
5
35
not evaluable
Neonatal infections
Elsenity, 2022
1
0.40
[
0.11
; 1.48]
8
33
not evaluable
Neonatal medical care
Elsenity, 2022
1
0.31
[
0.03
; 3.04]
11
33
not evaluable
Intrauterine deaths
Intrauterine deaths (as a whole or unspecified)
Mekinian, 2015 Mekinian, 2016 Sciascia, 2016 Ye, 2017 Ruffatti, 2018 Gerde, 2021 Elsenity, 2022
7
0.37
[
0.21
; 0.65]
493
437
not evaluable
Early intrauterine death (< 22 weeks)
Sciascia, 2016 Ye, 2017 Gerde, 2021
3
0.29
[
0.09
; 0.95]
110
246
not evaluable
Late intrauterine deaths (> 22 weeks)
Ye, 2017
1
1.12
[
0.27
; 4.59]
8
126
not evaluable
0.0
5.0
1.0
