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Trimethadione (Epilepsy = ALL)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Bànhidy (Trimethadione), 2011
1
0.83
[
0.05
; 15.09]
13
2
not evaluable
Congenital heart defects
Bànhidy (Trimethadione), 2011
1
1.73
[
0.03
; 99.96]
5
1
not evaluable
Hypospadias
Bànhidy (Trimethadione), 2011
1
2.71
[
0.04
; 164.95]
3
1
not evaluable
Major congenital malformations
Bànhidy (Trimethadione), 2011
1
0.83
[
0.05
; 15.09]
13
2
not evaluable
Neural Tube Defects
Bànhidy (Trimethadione), 2011
1
6.33
[
0.09
; 458.24]
1
1
not evaluable
Polydactyly
Bànhidy (Trimethadione), 2011
1
5.00
[
0.21
; 117.90]
3
2
not evaluable
Spina bifida
0
-
-
-
-
-
0.0
100.0
1.0