Trimethadione (Epilepsy = ALL)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk

Study	Country Study period	Case	Control	Sample size	Rmk
Bànhidy (Trimethadione), 2011	Hungary 1980 - 1996	Children affected with congenital abnormalities and who had mothers with medically recorded epilepsy.	Newborn infants without congenital abnormality and who had mothers with medically recorded epilepsy.	95 / 90	Congenital abnormalities syndromes caused by major mutant genes or chromosomal aberrations with preconceptional origin were excluded. Exposure period completed with Czeizel 1992.
Czeizel (Trimethadione), 1992	Hungary 1980 - 1987	Children affected with congenital abnormalities born from treated or untreated mothers.	Children without congenital abnormalities born from treated or untreated mothers.	100 / 54	The study design was partly completed thanks to the reference [6] cited in the publication. All congenital abnormalities except spina bifida are overlapped by the publication of Bànhidy 2011.