Miconazole (local route only)

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Kazy, 2005 Rotem, 2018 21.27[1.03; 1.58]28,648668not evaluable Cleft lip with or without cleft palate Kazy, 2005 Rotem, 2018 22.43[0.91; 6.47]1,502530not evaluable Congenital heart defects Kazy, 2005 Rotem, 2018 21.11[0.73; 1.69]6,886543not evaluable Major congenital malformations Kazy, 2005 Rotem, 2018 21.27[1.03; 1.58]28,648668not evaluable Ano-rectal atresia and stenosis Kazy, 2005 18.80[0.92; 84.25]220207not evaluable Cleft palate Kazy, 2005 11.90[0.42; 8.55]582207not evaluable Club foot / Talipes equinovarus Kazy, 2005 10.90[0.42; 1.91]2,424214not evaluable Digestive system anomalies Rotem, 2018 12.05[0.51; 8.29]301313not evaluable Ear malformations Kazy, 2005 10.26[0.02; 4.25]354203not evaluable Gastroschisis Kazy, 2005 12.90[0.31; 27.31]238207not evaluable Hydrocephaly Kazy, 2005 11.60[0.09; 27.94]314204not evaluable Hypospadias Kazy, 2005 11.00[0.53; 1.90]3,038222not evaluable Limb defects Rotem, 2018 12.10[1.12; 3.94]1,437313not evaluable Limb reduction defects (LRD) Kazy, 2005 10.40[0.09; 1.88]548205not evaluable Nervous system anomalies Rotem, 2018 11.10[0.35; 3.45]792313not evaluable Neural Tube Defects Kazy, 2005 11.20[0.48; 2.99]1,202212not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula Kazy, 2005 11.90[0.30; 12.22]217206not evaluable Polydactyly Kazy, 2005 16.00[2.38; 15.10]1,744224not evaluable Intrauterine deaths Early intrauterine death (< 22 weeks) Daniel, 2018 11.34[0.99; 1.81]6,367633not evaluable0.0100.01.0

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