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Oxazepam (Psy and mixed indications)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Källén, 2013
1
1.01
[
0.72
; 1.41]
49,532
843
not evaluable
Cleft lip with or without cleft palate
Cornel - The NNL registry, 1996
1
8.17
[
1.41
; 47.28]
277
8
not evaluable
Congenital heart defects
Källén, 2013
1
0.99
[
0.55
; 1.78]
2
843
not evaluable
Genetic syndromes and microdeletions
Bonnot, 2001
1
0.43
[
0.23
; 0.81]
2,280
28
not evaluable
Major congenital malformations
Källén, 2013
1
1.01
[
0.72
; 1.41]
49,532
843
not evaluable
Intrauterine deaths
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions
Sheehy, 2019
1
1.48
[
1.02
; 2.14]
27,149
160
not evaluable
0.2
50.0
1.0