Etizolam - Medication and Pregnancy KB

Etizolam

Exposed non-exposed, cohort studies

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Noh 2022	South Korea 2011 - 2018 population based cohort retrospective	A nationwide retrospective cohort study using healthcare data retrieved from the Health Insurance Review and Assessment Service (HIRA) database.	Pregnant women who filled at least Etizolam prescription during the first trimester (first 90 days of pregnancy).	unexposed, sick Pregnant women who were not prescribed any benzodiazepine from 3 months before the last menstrual period to the end of the first trimester (with similar psychiatric conditions after propensity score).	1st trimester	3665 / 3053381	Propensity scored adjusted for indications and led to an unexposed cohort with similar psychiatric conditions => considered as unexposed, sick control groups.
Noh 2022			The Health Insurance Review and Assessment Service (HIRA) database that comprises notably healthcare utilization (e.g., drug prescription and medical procedure).		1st trimester	3665 / 3053381
Yamane 2011	Japan Not specified. cohort	The Counseling Clinic for Pregnancy and Medicine of Toranomon Hospital, Tokyo, Japan.	Pregnant women who used Etizolam in the early stage of pregnancy.	unexposed (general population or NOS) Pregnant women who used acetaminophen without teratogenic effects.	early pregnancy	224 / -9	Number of pregnant women in the control group not provided in the Abstract.
Yamane 2011	Japan Not specified. cohort		Not specified.		early pregnancy	224 / -9

Case-control studies

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;

Empty. There are no case-control studies available for this drug.

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