MAOIs (Monoamine oxidase inhibitors)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Yaris 2005	Turkey 1999 - 2004 prospective cohort	Toxicology Information and Follow-up Service, Turkey.	Women who were exposed to Monoamine oxidase inhibitors (MAOIs) during pregnancy for depression, anxiety, and psychotic disorders. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed (general population or NOS) Women who did not use any drug while pregnant.	during pregnancy (anytime or not specified)	7 / 248	Raw data for Intrauterine exitus not reported because the nb of cases in the unexposed group not clearly stated. Raw data for premature delivery not reported because the denominator is not clearly stated.
Yaris 2005	Turkey 1999 - 2004 prospective cohort	Toxicology Information and Follow-up Service, Turkey.	Data surveyed by the interviews.		during pregnancy (anytime or not specified)	7 / 248

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Greenberg 1977	United Kingdom (England and Wales). 1969 - 1974 case control	The information passed in the Office of population censuses and surveys (OPCS), United Kingdom.	Children with congenital abnormalities (all minor malformations were eliminated).	Children without congenital abnormalities born in the same practice within 3 months of the date of birth of an abnormal baby.	Medical officers or community physicians were asked to identify the baby and the general practitioner, who was then interviewed by one of the Committee's medical field workers notably about drugs prescribed during the first trimester (only information obtained from written notes was used).	1st trimester	836 / 836
Greenberg 1977			The doctor, midwife, or health visitor attending the birth of an abnormal baby may report the abnormality to the area health authority. This information is then passed to the OPCS. Though voluntary, it is believed that notification of visible and severe malformations is reasonably complete.			1st trimester	836 / 836

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;