Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13645
R52899		 Bérard, 2021 Low birth weight (birthweight < 2,500g) during pregnancy (anytime or not specified) nested case control unexposed (general population or NOS) Adjustment: Yes Indication HCQ: Any or not specified 1.22 [0.57;2.62] 13/103   11,593/230,972 11,606 103
ref
Total 1 studies 1.22 [0.57;2.62] 11,606 103
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2021Bérard, 2021 1.22[0.57; 2.62]11,6061030%ROB confusion: seriousROB selection: lowROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.22[0.57; 2.62]11,606103 -NABérard, 2021 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.22[0.57; 2.62]11,606103 -NABérard, 2021 1 Tags Adjustment   - Yes  - Yes 1.22[0.57; 2.62]11,606103 -NABérard, 2021 1 Indication HCQ   - Any or not specified  - Any or not specified 1.22[0.57; 2.62]11,606103 -NABérard, 2021 1 All studiesAll studies 1.22[0.57; 2.62]11,606103 -NABérard, 2021 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.22[0.57; 2.62]11,606103 -NABérard, 2021 1 unexposed, sick controlsunexposed, sick controls 0.83[0.40; 1.74]15124454%NAReynolds, 2022 Tang, 2022 Louthrenoo, 2021 Leroux, 2015 40.510.01.0

Umbrella review (other published meta-analyses)

Published MATE95% CIn exposedkI2Control groupExposition period Duan (SLE indication)Duan (SLE indication) 0.77[0.43; 1.39]38%-unexposed, sickthroughout pregnancystudies5 Guillotin (SLE indication)Guillotin (SLE indication) 0.62[0.24; 1.64]66%-whatever (meta-analysis)throughout pregnancystudies5 Kaplan (All indications)Kaplan (All indications) 0.69[0.21; 2.27]72%-whatever (meta-analysis)at least 1st trimesterstudies2 metaPregmetaPreg 1.22[0.57; 2.62]NaN%103--Bérard, 2021 10.510.01.0