Leflunomide

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2900
R4095		 Bérard, 2018 Preterm (< 37 GW) 2nd and/or 3rd trimester nested case control unexposed (general population or NOS) Adjustment: Yes 4.03 [0.91;17.85] 7/21   10,818/154,324 10,825 21
ref
Total 1 studies 4.03 [0.91;17.85] 10,825 21
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Bérard, 2018Bérard, 2018 4.03[0.91; 17.85]10,825210%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 4.03[0.91; 17.85]10,82521 -NABérard, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.03[0.91; 17.85]10,82521 -NABérard, 2018 1 Tags Adjustment   - Yes  - Yes 4.03[0.91; 17.85]10,82521 -NABérard, 2018 1 All studiesAll studies 4.03[0.91; 17.85]10,82521 -NABérard, 2018 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 6.05[2.55; 14.36]10,850770%NABérard, 2018 Chambers (Unexposed control, disease free), 2010 2 unexposed, sick controlsunexposed, sick controls 1.74[0.85; 3.57]4356 -NAChambers (Unexposed control, sick), 2010 10.510.01.0