Leflunomide

Preterm (< 37 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2970
R4183		 Chambers (Unexposed control, disease free), 2010 Preterm delivery (<37 weeks) 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 7.44 [2.58;21.50] C
excluded (control group) 		20/56   5/72 25 56
ref
S2969
R4170		 Chambers (Unexposed control, sick), 2010 Preterm delivery (<37 weeks) 1st trimester prospective cohort unexposed, sick Adjustment: No 1.74 [0.85;3.57] C 20/56   23/95 43 56
ref
Total 1 studies 1.74 [0.85;3.57] 43 56
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Chambers (Unexposed control, sick), 2010Chambers, 2010 1 1.74[0.85; 3.57]43560%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.74[0.85; 3.57]4356 -NAChambers (Unexposed control, sick), 2010 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.74[0.85; 3.57]4356 -NAChambers (Unexposed control, sick), 2010 1 Tags Adjustment   - No  - No 1.74[0.85; 3.57]4356 -NAChambers (Unexposed control, sick), 2010 1 All studiesAll studies 1.74[0.85; 3.57]4356 -NAChambers (Unexposed control, sick), 2010 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2970

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 6.05[2.55; 14.36]10,850770%NABérard, 2018 Chambers (Unexposed control, disease free), 2010 2 unexposed, sick controlsunexposed, sick controls 1.74[0.85; 3.57]4356 -NAChambers (Unexposed control, sick), 2010 10.510.01.0