Ondansetron

Atrial septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S2852
R3866		 Huybrechts (Control exposed to other treatment), 2018 Secundum atrial septal defect 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: Yes 1.08 [0.90;1.30]
excluded (control group) 		147/55,579   373/185,699 520 55,579
ref
S2844
R3836		 Huybrechts (Unexposed control), 2018 Secundum atrial septal defect 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.00 [0.88;1.15] 216/88,446   3,080/1,727,546 3,296 88,446
ref
S2746
R3890		 Pasternak, 2013 Atrial septal defect 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: No 0.89 [0.30;2.63] C 4/1,233   18/4,932 22 1,233
ref
Total 2 studies 1.00 [0.87;1.14] 3,318 89,679
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Huybrechts (Unexposed control), 2018Huybrechts, 2018 1 1.00[0.88; 1.15]3,29688,44699%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Pasternak, 2013Pasternak, 2013 0.89[0.30; 2.63]221,2331%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.00[0.87; 1.14]3,31889,6790.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Unexposed control;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.00[0.87; 1.14]3,31889,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.00[0.87; 1.14]3,31889,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 2 Tags Adjustment   - No  - No 0.89[0.30; 2.63]221,233 -NAPasternak, 2013 1   - Yes  - Yes 1.00[0.87; 1.14]3,29688,446 -NAHuybrechts (Unexposed control), 2018 1 All studiesAll studies 1.00[0.87; 1.14]3,31889,6790%NAHuybrechts (Unexposed control), 2018 Pasternak, 2013 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2852

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.19[0.83; 1.71]4,14690,57289%NAZambelli-Weiner (Unexposed control, NOS), 2019 Huybrechts (Unexposed control), 2018 Pasternak, 2013 3 unexposed, sick controlsunexposed, sick controls 0.85[0.64; 1.14]1,5696930%NAParker, BDS study, 2018 Parker, NBDPS study, 2018 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.08[0.90; 1.30]52055,579 -NAHuybrechts (Control exposed to other treatment), 2018 10.510.01.0