Leflunomide - Medication and Pregnancy KB

Leflunomide

Preterm (< 37 weeks)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S2900 R4095	Bérard, 2018	Preterm (< 37 GW)	2nd and/or 3rd trimester	nested case control	unexposed (general population or NOS)	Adjustment: Yes	4.03 [0.91;17.85]	7/21 10,818/154,324	10,825	21		ref
S2970 R4183	Chambers (Unexposed control, disease free), 2010	Preterm delivery (<37 weeks)	1st trimester	prospective cohort	unexposed, disease free excluded	Adjustment: No	7.44 [2.58;21.50] ^C excluded (control group)	20/56 5/72	25	56		ref
S2969 R4170	Chambers (Unexposed control, sick), 2010	Preterm delivery (<37 weeks)	1st trimester	prospective cohort	unexposed, sick	Adjustment: No	1.74 [0.85;3.57] ^C	20/56 23/95	43	56		ref
					Total	2 studies	2.04 [1.07;3.90]		10,868	77
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Unexposed control, sick;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 2970