Bupropion (All indications except smoking cessation)

Study Reference
Anderson, 2020

Alwan Maternal use of bupropion and risk for congenital heart defects. Am J Obstet Gynecol 2010; 203:52.e1-6

Anderson Maternal Use of Specific Antidepressant Medications During Early Pregnancy and the Risk of Selected Birth Defects. JAMA Psychiatry 2020; 77(12):1246-1255.

Lind Maternal medication and herbal use and risk for hypospadias: data from the National Birth Defects Prevention Study, 1997-2007. Pharmacoepidemiol Drug Saf 2013; 22:783-93

Nembhard Maternal and infant genetic variants, maternal periconceptional use of selective serotonin reuptake inhibitors, and risk of congenital heart defects in offspring: population based study. BMJ 2017; 356:j832

Chun-Fai-Chan (Controls exposed to other antidepressants), 2005

Chun-Fai-Chan Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 2005; 192:932-6

Einarson A Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry 2009;54:242-6

Chun-Fai-Chan (Controls unexposed, NOS), 2005

Chun-Fai-Chan Pregnancy outcome of women exposed to bupropion during pregnancy: a prospective comparative study. Am J Obstet Gynecol 2005; 192:932-6

Einarson A Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry 2009;54:242-6

Cole, 2007

Cole Bupropion in pregnancy and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf 2007; 16:474-84

Einarson, 2009

Einarson A Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry 2009;54:242-6

Figueroa, 2010

Figueroa Use of antidepressants during pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring. J Dev Behav Pediatr 2010; 31:641-8

Huybrechts (Controls unexposed, NOS), 2014

Huybrechts KF Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med 2014;370:2397-407

Huybrechts (Controls unexposed, sick), 2014

Huybrechts KF Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med 2014;370:2397-407

Jackson, 2024

Jackson, F.I. Association between psychopharmacotherapy and postpartum hemorrhage AJOG Glob. Rep. 2024; 4:360-.

Kjaersgaard, 2013

Kjaersgaard Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study. PLoS One 2013; 8:e72095

Laspro, 2024

Laspro Association of Commonly Prescribed Antepartum Medications and Incidence of Orofacial Clefting. Cleft Palate Craniofac J 2024; :10556656241237679

Louik, 2014

Louik First-trimester exposure to bupropion and risk of cardiac malformations. Pharmacoepidemiol Drug Saf 2014; 23:1066-75

Marks (Controls exposed to Sertraline), 2021

Marks Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study. Pharmacotherapy 2021; 41:907-914

Marks (Controls unexposed, sick), 2021

Marks Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study. Pharmacotherapy 2021; 41:907-914

Newport, 2016

Newport Prenatal Psychostimulant and Antidepressant Exposure and Risk of Hypertensive Disorders of Pregnancy. J Clin Psychiatry 2016; 77:1538-1545

Ozturk, 2016

Ozturk, Z. Safety of psychotropic medications in pregnancy: An observational cohort study Klinik Psikofarmakoloji Bulteni 2016; 26:229-.

Palmsten (control exposed to SSRIs), 2013

Palmsten Antidepressant use and risk for preeclampsia. Epidemiology 2013; 24:682-91

Palmsten (Controls unexposed, sick), 2013

Palmsten Antidepressant use and risk for preeclampsia. Epidemiology 2013; 24:682-91

Palmsten b, 2013

Palmsten Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States. BMJ 2013; 347:f4877

Suarez (Controls unexposed, discontinuers), 2022

Suarez Association of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children. JAMA Intern Med 2022; 182:1149-60

Suarez (Controls unexposed, general pop), 2022

Suarez Association of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children. JAMA Intern Med 2022; 182:1149-60

Thyagarajan, 2012

Thyagarajan Bupropion therapy in pregnancy and the occurrence of cardiovascular malformations in infants. Pharmacoepidemiol Drug Saf 2012; 21:1240-2

Yaris, 2005

Yaris Psychotropic drugs in pregnancy: a case-control study. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29:333-8

Yeh, 2021

Yeh Bipolar women's antepartum psychotropic exposure and offspring risk of attention-deficit/hyperactivity disorder and autism spectrum disorder. J Affect Disord 2021; 295:1407-1414