| Study |
Reference |
|
Abadie, 2015
|
Abadie Medication exposure and spontaneous abortion: a case-control study using a French medical database. Clin Exp Obstet Gynecol 2015; 42:431-6 Abadie, D. Drug use and spontaneous abortion: A case/control study Pharmacoepidemiol. Drug Saf. 2012; 21:391-. Abadie, D. Drug use and spontaneous abortion: A case-control study Drug Saf. 2011; 34:1001-.
|
|
Anderson, 2020
|
Anderson Maternal Use of Specific Antidepressant Medications During Early Pregnancy and the Risk of Selected Birth Defects. JAMA Psychiatry 2020; 77(12):1246-1255.
|
|
Avalos (Controls exposed to SSRIs), 2015
|
Avalos Antidepressant medication use, depression, and the risk of preeclampsia. CNS Spectr 2015; 20:39-47
|
|
Avalos (Controls unexposed, disease free), 2015
|
Avalos Antidepressant medication use, depression, and the risk of preeclampsia. CNS Spectr 2015; 20:39-47
|
|
Avalos (Controls unexposed, sick), 2015
|
Avalos Antidepressant medication use, depression, and the risk of preeclampsia. CNS Spectr 2015; 20:39-47
|
|
Bahat, 2020
|
Bahat, M. Pregnancy outcome after first trimester exposure to Duloxetine Reprod. Toxicol. 2020; 97:3-.
|
|
Ban (Controls exposed to SSRIs), 2014
|
Ban L Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study. BJOG 2014;121:1471-81 Ban, L. Risks of major congenital anomaly in the children of women with clinically diagnosed depression: A population-based cohort study from the United Kingdom BJOG Int. J. Obstet. Gynaecol. 2013; 120:2-. Petersen Selective serotonin reuptake inhibitors and congenital heart anomalies: comparative cohort studies of women treated before and during pregnancy and their children. J Clin Psychiatry 2016; 77:e36-42
|
|
Ban (Controls exposed to SSRIs), 2012
|
Ban Live and non-live pregnancy outcomes among women with depression and anxiety: a population-based study. PLoS One 2012; 7:e43462
|
|
Ban (Controls unexposed, disease free), 2014
|
Ban L Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study. BJOG 2014;121:1471-81 Ban, L. Risks of major congenital anomaly in the children of women with clinically diagnosed depression: A population-based cohort study from the United Kingdom BJOG Int. J. Obstet. Gynaecol. 2013; 120:2-. Petersen Selective serotonin reuptake inhibitors and congenital heart anomalies: comparative cohort studies of women treated before and during pregnancy and their children. J Clin Psychiatry 2016; 77:e36-42
|
|
Ban (Controls unexposed, disease free), 2012
|
Ban Live and non-live pregnancy outcomes among women with depression and anxiety: a population-based study. PLoS One 2012; 7:e43462
|
|
Ban (Controls unexposed, sick), 2014
|
Ban L Maternal depression, antidepressant prescriptions, and congenital anomaly risk in offspring: a population-based cohort study. BJOG 2014;121:1471-81 Ban, L. Risks of major congenital anomaly in the children of women with clinically diagnosed depression: A population-based cohort study from the United Kingdom BJOG Int. J. Obstet. Gynaecol. 2013; 120:2-. Petersen Selective serotonin reuptake inhibitors and congenital heart anomalies: comparative cohort studies of women treated before and during pregnancy and their children. J Clin Psychiatry 2016; 77:e36-42
|
|
Ban (Controls unexposed, sick), 2012
|
Ban Live and non-live pregnancy outcomes among women with depression and anxiety: a population-based study. PLoS One 2012; 7:e43462
|
|
Bérard (Controls exposed to SSRIs), 2017
|
Bérard Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort. BMJ Open 2017; 7:e013372 Ramos Duration of antidepressant use during pregnancy and risk of major congenital malformations. Br J Psychiatry 2008; 192:344-50
|
|
Bérard (Controls unexposed, sick), 2017
|
Bérard Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: an updated analysis of the Quebec Pregnancy Cohort. BMJ Open 2017; 7:e013372 Bérard, A. Antidepressant use during pregnancy and the risk of major congenital malformations in a cohort of depressed pregnant women: A re-analysis of the Quebec pregnancy cohort Eur. Psychiatry 2017; 41:S155-. Ramos Duration of antidepressant use during pregnancy and risk of major congenital malformations. Br J Psychiatry 2008; 192:344-50
|
|
Bernard, 2019
|
Bernard Use of antidepressants and anxiolytics in early pregnancy and the risk of preeclampsia and gestational hypertension: a prospective study. BMC Pregnancy Childbirth 2019; 19:146
|
|
Boukhris (Controls exposed to SSRIs), 2016
|
Bérard Selective serotonin reuptake inhibitors and autism: additional data on the Quebec Pregnancy/Birth Cohort. Am J Obstet Gynecol 2016; 215:803-805 Boukhris T Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children. JAMA Pediatr 2016;170:117-24
|
|
Boukhris (Controls exposed to SSRIs), 2017
|
Boukhris Antidepressant Use in Pregnancy and the Risk of Attention Deficit with or without Hyperactivity Disorder in Children. Paediatr Perinat Epidemiol 2017; 31:363-373
|
|
Boukhris (Controls unexposed, NOS), 2016
|
Bérard Selective serotonin reuptake inhibitors and autism: additional data on the Quebec Pregnancy/Birth Cohort. Am J Obstet Gynecol 2016; 215:803-805 Boukhris T Antidepressant Use During Pregnancy and the Risk of Autism Spectrum Disorder in Children. JAMA Pediatr 2016;170:117-24
|
|
Boukhris (Controls unexposed, NOS), 2017
|
Boukhris Antidepressant Use in Pregnancy and the Risk of Attention Deficit with or without Hyperactivity Disorder in Children. Paediatr Perinat Epidemiol 2017; 31:363-373
|
|
Chan (Controls exposed to SSRIs), 2024
|
Chan Prenatal antidepressant use and risk of congenital malformations: A population-based cohort study. Psychiatry Res 2024; 339:116038
|
|
Chan (Controls unexposed, general pop), 2024
|
Chan Prenatal antidepressant use and risk of congenital malformations: A population-based cohort study. Psychiatry Res 2024; 339:116038
|
|
Chan (Controls unexposed, sick), 2024
|
Chan Prenatal antidepressant use and risk of congenital malformations: A population-based cohort study. Psychiatry Res 2024; 339:116038
|
|
Chen, 2021
|
Chen Association between the use of antidepressants and the risk of preterm birth among pregnant women with depression: a retrospective cohort study in Taiwan. J Investig Med 2021; 69:999-1007
|
|
Croen, 2011
|
Croen LA Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry 2011;68:1104-12
|
|
Dandjinou, 2019
|
Dandjinou Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case-control study. BMJ Open 2019; 9:e025908 Dandjinou, M. Antidepressants use during pregnancy and the risk of gestational diabetes mellitus Pharmacoepidemiol. Drug Saf. 2018; 27:378-.
|
|
Davis, 2007
|
Davis Risks of congenital malformations and perinatal events among infants exposed to antidepressant medications during pregnancy. Pharmacoepidemiol Drug Saf 2007; 16:1086-94
|
|
De Vera, 2012
|
De Vera Antidepressant use during pregnancy and the risk of pregnancy-induced hypertension. Br J Clin Pharmacol 2012; 74:362-9
|
|
Greenberg, 1977
|
Greenberg Maternal drug histories and congenital abnormalities. Br Med J 1977; 2:853-6
|
|
Hagberg (Controls exposed to SSRIs), 2018
|
Hagberg Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring. Clin Epidemiol 2018; 10:1599-1612
|
|
Hagberg (Controls unexposed, disease free), 2018
|
Hagberg Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring. Clin Epidemiol 2018; 10:1599-1612
|
|
Hagberg (Controls unexposed, sick), 2018
|
Hagberg Maternal depression and antidepressant use during pregnancy and the risk of autism spectrum disorder in offspring. Clin Epidemiol 2018; 10:1599-1612
|
|
Hartwig, 2022
|
Hartwig In utero antidepressant exposure not associated with ADHD in the offspring: A case control sibling design. Front Pharmacol 2022; 13:1000018
|
|
Heuvelman, 2023
|
Heuvelman Antidepressants in pregnancy: applying causal epidemiological methods to understand service-use outcomes in women and long-term neurodevelopmental outcomes in exposed children. Health Technol Assess 2023; 27:1-83
|
|
Huybrechts (Controls unexposed, NOS), 2014
|
Huybrechts KF Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med 2014;370:2397-407
|
|
Huybrechts (Controls unexposed, sick), 2014
|
Huybrechts KF Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med 2014;370:2397-407
|
|
Källen, 2013
|
Källen B The use of central nervous system active drugs during pregnancy. Pharmaceuticals (Basel) 2013;6:1221-86
|
|
Källén (Controls exposed to SSRIs), 2004
|
Källen Neonate characteristics after maternal use of antidepressants in late pregnancy. Arch Pediatr Adolesc Med 2004;158:312-6
|
|
Källén (Controls unexposed, NOS), 2004
|
Källen Neonate characteristics after maternal use of antidepressants in late pregnancy. Arch Pediatr Adolesc Med 2004;158:312-6
|
|
Kieler, 2015
|
Kieler Use of antidepressants and association with elective termination of pregnancy: population based case-control study. BJOG 2015; 122:1618-24
|
|
Kitchin, 2022
|
Kitchin The role of prenatal exposure to antidepressants, anxiolytic, and hypnotics and its underlying illness on the risk of miscarriage using BIFAP database. Pharmacoepidemiol Drug Saf 2022; :
|
|
Kjaersgaard (Controls unexposed, NOS), 2013
|
Kjaersgaard Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study. PLoS One 2013; 8:e72095
|
|
Kjaersgaard (Controls unexposed, sick), 2013
|
Kjaersgaard Prenatal antidepressant exposure and risk of spontaneous abortion - a population-based study. PLoS One 2013; 8:e72095
|
|
Kolding (Controls unexposed, disease free), 2021
|
Kolding Antidepressant use in pregnancy and severe cardiac malformations: Danish register-based study. BJOG 2021; 128:1949-1957
|
|
Kolding (Controls unexposed, sick), 2021
|
Kolding Antidepressant use in pregnancy and severe cardiac malformations: Danish register-based study. BJOG 2021; 128:1949-1957
|
|
Kullander - Imipramine, 1976
|
Kullander A prospective study of drugs and pregnancy. I. Psychopharmaca. Acta Obstet Gynecol Scand 1976; 55:25-33
|
|
Laugesen, 2013
|
Laugesen In utero exposure to antidepressant drugs and risk of attention deficit hyperactivity disorder: a nationwide Danish cohort study. BMJ Open 2013; 3:e003507
|
|
Lee (Controls exposed to SSRI), 2025
|
Lee Antidepressant use during pregnancy and risk of obstetrics and neonatal outcomes: A propensity score-weighted population-based cohort study in 2003-2018. Eur Neuropsychopharmacol 2025; 96:36-45
|
|
Lee (Controls unexposed, general pop), 2025
|
Lee Antidepressant use during pregnancy and risk of obstetrics and neonatal outcomes: A propensity score-weighted population-based cohort study in 2003-2018. Eur Neuropsychopharmacol 2025; 96:36-45
|
|
Liu, 2015
|
Liu Antidepressant use during pregnancy and asthma in the offspring. Pediatrics 2015; 135:e911-7
|
|
Louik, 2014
|
Louik First-trimester exposure to bupropion and risk of cardiac malformations. Pharmacoepidemiol Drug Saf 2014; 23:1066-75
|
|
Lupattelli (Controls exposed to SSRIs), 2017
|
Lupattelli Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study. Pharmacoepidemiol Drug Saf 2017; 26:1266-1276
|
|
Lupattelli (Controls unexposed, sick), 2017
|
Lupattelli Risk of preeclampsia after gestational exposure to selective serotonin reuptake inhibitors and other antidepressants: A study from The Norwegian Mother and Child Cohort Study. Pharmacoepidemiol Drug Saf 2017; 26:1266-1276
|
|
Martin - Amitriptyline, 2024
|
Martin Antidepressant use during pregnancy and birth outcomes: analysis of electronic health data from the UK, Norway, and Sweden. medRxiv 2024; :
|
|
Nakhai-Pour, 2010
|
Nakhai-Pour Use of antidepressants during pregnancy and the risk of spontaneous abortion. CMAJ 2010; 182:1031-7
|
|
Nijenhuis (Controls exposed to SSRIs), 2012
|
Nijenhuis Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 2: Testing the hypotheses. Br J Clin Pharmacol 2012; 73:126-34
|
|
Nijenhuis (Controls unexposed, NOS), 2012
|
Nijenhuis Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 2: Testing the hypotheses. Br J Clin Pharmacol 2012; 73:126-34
|
|
Nulman (Controls exposed to Fluoxetine), 1997
|
Nulman I Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 1997;336:258-62
|
|
Nulman (Controls unexposed, disease free), 2002
|
Nulman Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study. Am J Psychiatry 2002; 159:1889-95
|
|
Nulman (Controls unexposed, NOS), 1997
|
Nulman I Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 1997;336:258-62
|
|
Nulman - Fluoxetine (Controls exposed to Fluoxetine), 2002
|
Nulman Child development following exposure to tricyclic antidepressants or fluoxetine throughout fetal life: a prospective, controlled study. Am J Psychiatry 2002; 159:1889-95
|
|
Ozturk - Amitriptyline, 2016
|
Ozturk Safety of psychotropic medications in pregnancy: An observational cohort study Klinik Psikofarmakoloji Bulteni 2016; 26:229-.
|
|
Palmsten (Controls exposed to SSRIs), 2012
|
Palmsten Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants? Am. J. Epidemiol. 2012; 175:988-97
|
|
Palmsten (Controls unexposed, sick), 2012
|
Palmsten Elevated risk of preeclampsia in pregnant women with depression: depression or antidepressants? Am. J. Epidemiol. 2012; 175:988-97
|
|
Palmsten a (control exposed to SSRIs), 2013
|
Palmsten Antidepressant use and risk for preeclampsia. Epidemiology 2013; 24:682-91
|
|
Palmsten a (Controls unexposed, sick), 2013
|
Palmsten Antidepressant use and risk for preeclampsia. Epidemiology 2013; 24:682-91
|
|
Palmsten b, 2013
|
Palmsten Use of antidepressants near delivery and risk of postpartum hemorrhage: cohort study of low income women in the United States. BMJ 2013; 347:f4877
|
|
Pastuszak (Controls exposed to Fluoxetine), 1993
|
Pastuszak A Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac) JAMA 1993;269:2246-8
|
|
Pastuszak (Controls unexposed, NOS), 1993
|
Pastuszak A Pregnancy outcome following first-trimester exposure to fluoxetine (Prozac) JAMA 1993;269:2246-8
|
|
Pearson (Controls exposed to SSRIs), 2007
|
Pearson Birth outcomes following prenatal exposure to antidepressants. J Clin Psychiatry 2007; 68:1284-9
|
|
Pearson (Controls unexposed, NOS), 2007
|
Pearson Birth outcomes following prenatal exposure to antidepressants. J Clin Psychiatry 2007; 68:1284-9
|
|
Pedersen, 2010
|
Pedersen Fetal exposure to antidepressants and normal milestone development at 6 and 19 months of age. Pediatrics 2010; 125:e600-8
|
|
Rai - Clomipramine only (Controls exposed to SSRIs), 2017
|
Rai Antidepressants during pregnancy and autism in offspring: population based cohort study. BMJ 2017; 358:j2811 Rai Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ 2013; 346:f2059
|
|
Rai - Clomipramine only (Controls unexposed, disease free), 2017
|
Rai Antidepressants during pregnancy and autism in offspring: population based cohort study. BMJ 2017; 358:j2811
|
|
Rai - Clomipramine only (Controls unexposed, sick), 2017
|
Rai Antidepressants during pregnancy and autism in offspring: population based cohort study. BMJ 2017; 358:j2811 Rai Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ 2013; 346:f2059
|
|
Reis (Controls exposed to SSRIs), 2010
|
Källen Neonatal complications after maternal concomitant use of SSRI and other central nervous system active drugs during the second or third trimester of pregnancy. J Clin Psychopharmacol 2012; 32:608-14 Källén Maternal drug use in early pregnancy and infant cardiovascular defect Reproductive Toxicology 2003; 17:255-. Reis Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data. Psychol Med 2010; 40:1723-33
|
|
Reis (Controls unexposed, NOS), 2010
|
Källen Neonatal complications after maternal concomitant use of SSRI and other central nervous system active drugs during the second or third trimester of pregnancy. J Clin Psychopharmacol 2012; 32:608-14 Källén Maternal drug use in early pregnancy and infant cardiovascular defect Reproductive Toxicology 2003; 17:255-. Reis Delivery outcome after maternal use of antidepressant drugs in pregnancy: an update using Swedish data. Psychol Med 2010; 40:1723-33
|
|
Simon (Controls exposed to SSRIs), 2002
|
Simon Outcomes of prenatal antidepressant exposure. Am J Psychiatry 2002; 159:2055-61
|
|
Simon (Controls unexposed, NOS), 2002
|
Simon Outcomes of prenatal antidepressant exposure. Am J Psychiatry 2002; 159:2055-61
|
|
Solé, 2020
|
Solé Obstetric complications in bipolar disorder: Psychiatric factors and the risk of caesarean section. Eur Neuropsychopharmacol 2020; 32:47-55
|
|
Song, 2023
|
Song Associations of Preterm Birth with Dental and Gastrointestinal Diseases: Machine Learning Analysis Using National Health Insurance Data. Int J Environ Res Public Health 2023; 20:
|
|
Suarez (Controls unexposed, discontinuers), 2022
|
Suarez Association of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children. JAMA Intern Med 2022; 182:1149-60
|
|
Suarez (Controls unexposed, general pop), 2022
|
Suarez Association of Antidepressant Use During Pregnancy With Risk of Neurodevelopmental Disorders in Children. JAMA Intern Med 2022; 182:1149-60
|
|
Sørensen (Controls exposed to SSRIs), 2013
|
Gidaya In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder. J Autism Dev Disord 2014; 44:2558-67 Hviid Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med 2013; 369:2406-15 Sorensen MJ Antidepressant exposure in pregnancy and risk of autism spectrum disorders. Clin Epidemiol 2013;5:449-59
|
|
Sørensen (Controls unexposed, NOS), 2013
|
Gidaya In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder. J Autism Dev Disord 2014; 44:2558-67 Hviid Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med 2013; 369:2406-15 Sorensen MJ Antidepressant exposure in pregnancy and risk of autism spectrum disorders. Clin Epidemiol 2013;5:449-59
|
|
Ter Host (Controls exposed to SSRIs), 2013
|
ter Horst In utero exposure to antidepressants and the use of drugs for pulmonary diseases in children. Eur J Clin Pharmacol 2013; 69:541-7
|
|
Ter Host (Controls unexposed, NOS), 2013
|
ter Horst In utero exposure to antidepressants and the use of drugs for pulmonary diseases in children. Eur J Clin Pharmacol 2013; 69:541-7
|
|
Tran (Controls exposed to SSRI), 2022
|
Tran Antidepressant use during pregnancy and development of preeclampsia: A focus on classes of action and specific transporters/receptors targeted by antidepressants. J Psychiatr Res 2022; 146:92-101
|
|
Tran (Controls unexposed, NOS), 2022
|
Tran Antidepressant use during pregnancy and development of preeclampsia: A focus on classes of action and specific transporters/receptors targeted by antidepressants. J Psychiatr Res 2022; 146:92-101
|
|
Vasilakis-Scaramozza (Controls exposed to SSRIs), 2013
|
Vasilakis-Scaramozza Antidepressant use during early pregnancy and the risk of congenital anomalies. Pharmacotherapy 2013; 33:693-700
|
|
Vasilakis-Scaramozza (Controls unexposed, NOS), 2013
|
Vasilakis-Scaramozza Antidepressant use during early pregnancy and the risk of congenital anomalies. Pharmacotherapy 2013; 33:693-700
|
|
Wall-Wieler, 2020
|
Wall-Wieler Antidepressant Use around Conception, Prepregnancy Depression, and Risk of Ectopic Pregnancy. Can J Psychiatry 2020; 65:845-853
|
|
Yang, 2021
|
Yang Prenatal antidepressant use and the implication of hypertensive disorders during pregnancy. Am J Obstet Gynecol 2021; 225:672.e1-672.e11
|
|
Yaris, 2005
|
Yaris Psychotropic drugs in pregnancy: a case-control study. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29:333-8
|
|
Zakiyah, 2018
|
Zakiyah Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study. BMC Pregnancy Childbirth 2018; 18:187
|
