Hydrochlorothiazide (versus unexposed) - Medication and Pregnancy KB

Hydrochlorothiazide (versus unexposed)

Exposed non-exposed studies (cohort)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Mabie, 1986	USA 1980 - 1984	Pregnant women with chronic hypertension (>= 140/90 mmHg before pregnancy or at less than 20 week's gestation) who delivered at this hospital during the study period.	Pregnant women with chronic hypertension treated with Hydrochlorothiazide only.	unexposed, sick Pregnant women with chronic hypertension without treatment.	10 / 82	Data on Hydrochlorothiazide only reported rather than co-administration Methyldopa and hydrochlorothiazide.

Case-control studies (cohort)

Study	Country Study period	Case	Control	Sample size	Rmk
Medveczky, 2004	Hungary 1980 - 1996	Newborn infants (including infant deaths and usual stillborn fetuses) with Neural tube defects with non-syndromic (i.e. isolated anencephaly, spina bifida aperta/cystica, encephalocele).	Newborn infants (including infant deaths and usual stillborn fetuses) without congenital abnormalities.	1202 / 38151	Study design completed with other studies published on the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA).
Van Zutphen, 2014	USA 1997 - 2009	All cases (liveborn, stillborn after 20 weeks gestation, or induced abortions) with severe hypospadias (ie, subcoronal or penile, scrotal, or perineal meatal opening) diagnosed at the time of physical examination, surgery, or autopsy.	Male live births without birth defects randomly selected from birth certificates or hospital discharge listings in the same population as the case neonates.	2131 / 5129	Mothers reporting antihypertensive medications for the treatment of other indications (eg, b-blockers for migraine headaches) were excluded from the analyses.
Vermes, 2015	Hungary 1980 - 1996	Newborn infants (including infant deaths and usual stillborn fetuses) with isolated Oesophageal Atresia.	Newborn infants (including infant deaths and usual stillborn fetuses) without congenital abnormalities.	221 / 356	Study design completed with other studies published on the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA). Cases with multiple/syndromic Oesophageal Atresia were excluded from the study.

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