Clonidine (versus unexposed)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Huisjes, 1986	The Netherlands 1974 - 1981	Women who had been delivered of a surviving infant at the Groningen University Hospital during the years 1974-1981.	Pregnant women who had been treated for hypertension or superimposed preeclampsia with clonidine only.	unexposed, sick Non-treated hypertensive gravidae matched for diastolic blood pressure during pregnancy, and sex, birthweight and gestational age of the children.	22 / 22	The start of the clonidine medication varied from before conception to 35 weeks gestational age and it was continued until delivery in all cases, dosages ranged from twice 75 microg to three times 150 microg.

Study	Country Study period	Case	Control	Sample size	Rmk

1 study, not fulfilled eligibility criteria, were excluded. See excluded tab for the list of these studies and reason of exclusion.