Lacosamide (Epilepsy)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Tomson (Lacosamide), 2018	42 countries 1999 - 2016	Pregnancies registered in the database during the study period who had been exposed to antiepileptic drug monotherapy and had complete follow-up data up to 1 year. They were enrolled within gestation week 16 and before fetal outcome is known.	Offspring exposed in utero to lacosamide monotherapy during the first trimester and born from epileptic mothers. (This is a subgroup of exposure among the whole exposed group considered in the study).	exposed to other treatment, sick Offspring exposed in utero to lamotrigine monotherapy during the first trimester and born from epileptic mothers.	8 / 2514	EURAP registry: potential overlap.

Study	Country Study period	Case	Control	Sample size	Rmk