Metronidazole (local route only)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk

1 study, not fulfilled eligibility criteria, were excluded. See excluded tab for the list of these studies and reason of exclusion.

Study	Country Study period	Case	Control	Sample size	Rmk
Kazy - Metronidazole, 2005	Hungary 1980 - 1996	Cases with congenital abnormalities (CAs) were selected from the Hungarian Congenital Abnormality Registry.	Controls were extracted from from the National Birth Registry of the Central Statistical Office.	22843 / 38151	The Hungarian Case–Control Surveillance of Congenital Abnormalities was used 2 times to assess vaginal Metronidazole (Kazy 2005a; b): to avoid redundancy of cases and controls, only 1 was used => metronidazole alone (rather than in association).
Zarante, 2009	Colombia 2001- 2006	All newborns and stillborns of weight >500 g that presented only one craniofacial malformation, not associated with any other congenital condition.	The next non-malformed same sex child born in the same hospital.	374 / 728