Ramipril (versus unexposed)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Colvin, 2010	Australia 2002 - 2005	All birth events in Western Australia (WA).	Ramipril dispensed from 14 days after the last menstrual period (LMP) to the end of first trimester or to the end of the pregnancy event. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed (general population or NOS) All other births (those births to women dispensed a Pharmaceutical Benefits Scheme (PBS) medicine or not).	22 / 106052	Category D or X medicines also studied. Total nb of unexposed: 106052=106074-22. Birth defect: structural or functional abnormality. Most minor defects are not recorded in the BDR. Of all cases, about 90% have at least one major birth defect.

Study	Country Study period	Case	Control	Sample size	Rmk