Study Type of data Exposure measurement Outcome assessment Adjustment
Gold, 2015 retrospective cohort Clinical studies with administration of DMF. The study treatment was discontinued immediately in the event of pregnancy. Not specified. None
Nguyen (control exposed to IFN), 2019 prospective cohort Data in the MSBase registry, including prospective pregnancy data, is entered in real time or near real time, as part of routine clinical visits. Information collected included: disease-modifying therapies exposure before and during pregnancy. Data in the MSBase registry, including prospective pregnancy data, is entered in real time or near real time, as part of routine clinical visits. Information collected included pregnancy outcomes. None
Nguyen (control unexposed, sick), 2019 prospective cohort Data in the MSBase registry, including prospective pregnancy data, is entered in real time or near real time, as part of routine clinical visits. Information collected included: disease-modifying therapies exposure before and during pregnancy. Data in the MSBase registry, including prospective pregnancy data, is entered in real time or near real time, as part of routine clinical visits. Information collected included pregnancy outcomes. None

master protocol