Furosemide (versus unexposed)

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Czeizel, 1999	case control	Exposure data collected from 3 sources: a post-paid structured questionnaire sent to the parents requesting drugs taken during pregnancy, according to gestational months; maternal prenatal care logbook (in which obstetricians must record all prescribed drugs); nurses visited non-responding families.	The Hungarian Congenital Abnormality Registry (HCAR), in which notification by physicians of cases with Congenital anomalies is mandatory (including infant deaths and usual stillborn fetuses). Controls were selected from the National Birth Registry of the Central Statistical Office.	Controls matched according to gender, birth week and district of parents’ residence. Maternal age did not show significant differences between the case and control groups. Adjusted for confounding factors (such as birth order and maternal disorders (no other details)).