Albendazole

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Celik, 2018	retrospective cohort	Data were obtained from the registry systems of two hospitals and from medical survey charts developed for pregnant women with hydatid disease (HD).	Data were obtained from the registry systems of two hospitals and from medical survey charts developed for pregnant women with hydatid disease (HD).	None.
Choi, 2017	prospective cohort	Each participant was given a questionnaire regarding exposure to alcohol, cigarettes or any other medication at recruitment and at every visit until delivery, or until lost to follow-up.	At delivery, all participants were admitted to the hospital, and at birth the babies were clinically examined by a neonatologist at 1st day of birth in order to identify congenital malformations (NOS).	Each case was age-matched (±2years) to control.
Gyapong, 2003	retrospective cohort	All women were visited and interviewed to find out if they had received the drugs. During the interviews, the women were also asked if they had been pregnant during the time of drug distribution, and/or if they had had a child since.	Two paediatricians examined all infants born to these women within 42 weeks of the period following treatment, for congenital malformations using a standardized instrument. Health facilities and local Traditional Birth Attendants were also visited to review maternity records.	None.
Mpairwe (Controls exposed to Praziquantel), 2011	randomized controlled trial	Pregnant women were allocated to one of the four treatment arms according to a random sequence. Participants and staff were blinded to treatment allocation.	Infants were seen at 6, 10 and 14 wk, 6, 9 and 12 months and at interim illness events.	No adjustment/match for this group of comparison. Randomisation.
Mpairwe (Controls unexposed, sick), 2011	randomized controlled trial	Pregnant women were allocated to one of the four treatment arms according to a random sequence. Participants and staff were blinded to treatment allocation.	Infants were seen at 6, 10 and 14 wk, 6, 9 and 12 months and at interim illness events.	Matching placebo (not otherwise specified). Randomisation.
Ndibazza (Controls exposed to praziquantel), 2010	randomized controlled trial	Participants were randomized and double-blind assigned to receive albendazole.	Infants were seen for at the research clinic. For babies not delivered in this Hospital, health card birth weight records were used. Anomalies were identified at birth by the midwife and accumulated to 1 year by physicians, supported, if necessary, by specialists.	None for this group of comparison. Randomisation.
Ndibazza (Controls unexposed, sick), 2010	randomized controlled trial	Participants were randomized and double-blind assigned to receive albendazole.	Infants were seen for at the research clinic. For babies not delivered in this Hospital, health card birth weight records were used. Anomalies were identified at birth by the midwife and accumulated to 1 year by physicians, supported, if necessary, by specialists.	Match controls (not otherwise specified). For each outcome, effects of albendazole versus its placebo and effects of praziquantel versus its placebo, adjusted for one another, were estimated using logistic regression or linear regression (not otherwise specified).
Ndyomugyenyi (Controls exposed to ivermectin), 2008	randomized controlled trial	Women were randomly assigned to receive albendazole administered as a single dose of 400 mg or ivermectin or a combination of both. The drugs were taken under direct supervision.	Abortions and premature deliveries were recorded in time relation to the administration of the drug through weekly community surveillance. The babies were examined for weight, any malformations and for clinical jaundice and anemia.	No adjustment. Randomisation.
Ndyomugyenyi (Controls unexposed, disease free), 2008	randomized controlled trial	Women were randomly assigned to receive albendazole administered as a single dose of 400 mg or ivermectin or a combination of both. The drugs were taken under direct supervision.	Abortions and premature deliveries were recorded in time relation to the administration of the drug through weekly community surveillance. The babies were examined for weight, any malformations and for clinical jaundice and anemia.	No adjustment. Randomisation.

master protocol