metaPreg - Triptans during pregnancy

Triptans

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	0.99 [0.85, 1.15]	0%	4 studies	57,146	4,397	not evaluable	ROB	-
Major congenital malformations	0.97 [0.81, 1.17]	0%	4 studies	39,057	4,392	not evaluable	ROB	-
Congenital heart defects	1.32 [0.61, 2.88]	57%	2 studies	13,707	2,839	not evaluable	ROB	-
Minor congenital malformations	0.68 [0.06, 8.05]	66%	2 studies	46	387	not evaluable	ROB	-
Eye defects	-	-	0 study					-
Urinary malformations	-	-	0 study					-
Abdominal wall defects	-	-	0 study					-
Ear, face and neck anomalies	-	-	0 study					-
Other anomalies/syndromes (non chromosomal)	-	-	0 study					-
Respiratory system anomalies	-	-	0 study					-
8 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	1.03 [0.71, 1.48]	73%	7 studies	4,470	2,480	not evaluable	ROB	-
Low birth weight (< 2500g)	0.92 [0.71, 1.19]	0%	5 studies	3,578	2,692	not evaluable	ROB	-
Small for gestational age (weight)	1.08 [0.85, 1.38]	0%	2 studies	299	1,861	not evaluable	ROB	-
1 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preeclampsia	1.25 [0.73, 2.14]	73%	3 studies	275	2,183	not evaluable	ROB	-
4 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
2 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	1.64 [0.94, 2.86]	66%	4 studies	5,012	686	not evaluable	ROB	-
Elective/induced termination of pregnancy	1.11 [0.42, 2.98]	15%	2 studies	108	508	not evaluable	ROB	-
Late intrauterine deaths (> 22 weeks)	0.65 [0.11, 3.86]	0%	2 studies	7	508	not evaluable	ROB	-
3 non statistically significant endpoints reported in only one study