metaPreg - Clobazam (Epilepsy) during pregnancy

Clobazam (Epilepsy) updated on 02-10-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	5.36 [1.56, 18.43]	16%	4 studies	135	36	not evaluable	ROB	10.20 [2.50; .]
Major congenital malformations	5.36 [1.56, 18.43]	16%	4 studies	135	36	not evaluable	ROB	10.20 [2.50; .]
Limb defects	13.00 [1.11, 152.71]	-	1 study	3	14	not evaluable	ROB	25.49 [1.45; .]
Nervous system anomalies	147.61 [6.70, 3253.00]	-	1 study	2	14	not evaluable	ROB	294.72 [12.88; .]
4 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
1 non statistically significant endpoints reported in only one study
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
2 non statistically significant endpoints reported in only one study