metaPreg - Esomeprazole during pregnancy

Esomeprazole

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.10 [1.02, 1.19]	0%	2 studies	108,332	13,184	not evaluable	ROB	1.44 [1.15; .]
Major congenital malformations	1.10 [1.02, 1.19]	0%	2 studies	108,332	13,184	not evaluable	ROB	1.44 [1.15; .]
Cleft palate	0.97 [0.53, 1.78]	-	1 study	2,292	12,516	not evaluable	ROB	-
Congenital heart defects	1.09 [0.97, 1.23]	-	1 study	42,434	12,516	not evaluable	ROB	-
Hydrocephaly	0.43 [0.11, 1.71]	-	1 study	786	12,516	not evaluable	ROB	-
Hypospadias	0.64 [0.30, 1.37]	-	1 study	1,806	6,476	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Extremely preterm (< 28 weeks)	1.13 [0.64, 1.99]	-	1 study		59	not evaluable	ROB	-
Low birth weight (< 2500g)	0.93 [0.86, 1.01]	-	1 study	104,782	12,868	not evaluable	ROB	-
Preterm (< 37 weeks)	1.07 [0.68, 1.68]	-	1 study		59	not evaluable	ROB	-
Small for gestational age (weight)	1.81 [0.87, 3.77]	-	1 study	68	59	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Abruptio placentae (retroplacental hematoma)	0.07 [0.00, 1.28]	-	1 study	6	59	not evaluable	ROB	-
Maternal consequences (as a whole)	0.24 [0.03, 2.23]	-	1 study	5	59	not evaluable	ROB	-
Postpartum hemorrhage	0.14 [0.01, 2.73]	-	1 study	3	59	not evaluable	ROB	-
Preeclampsia	0.14 [0.01, 2.73]	-	1 study	3	59	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Fetal distress	1.18 [0.57, 2.43]	-	1 study	54	59	not evaluable	ROB	-
Low Apgar score (< 7) (at 5 min)	0.13 [0.02, 1.10]	-	1 study	8	59	not evaluable	ROB	-
Necrotizing enterocolitis	1.38 [0.30, 6.46]	-	1 study	7	59	not evaluable	ROB	-
Neonatal death (< 28 days of life)	0.76 [0.26, 2.20]	-	1 study	16	59	not evaluable	ROB	-
Neonatal disorders (as a whole)	0.91 [0.35, 2.34]	-	1 study	21	59	not evaluable	ROB	-
Neonatal infections	1.98 [0.62, 6.31]	-	1 study	14	59	not evaluable	ROB	-
Neonatal intracranial hemorrhage	5.27 [0.25, 112.09]	-	1 study	2	59	not evaluable	ROB	-
Neonatal medical care	2.20 [0.62, 7.73]	-	1 study	12	59	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Late intrauterine deaths (> 22 weeks)	1.02 [0.06, 16.65]	-	1 study	2	59	not evaluable	ROB	-
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