Nortriptyline updated on 10-20-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.00 [0.27, 3.77]-1 study30,63011not evaluable ROB-
Major congenital malformations1.00 [0.27, 3.77]-1 study30,63011not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Large for gestational age (weight)0.62 [0.15, 2.54]-1 study9,746117not evaluable ROB-
Low birth weight (< 2500g)1.53 [0.92, 2.54]-1 study31,365117not evaluable ROB-
Preterm (< 37 weeks)0.94 [0.50, 1.75]-1 study28,554117not evaluable ROB-
Small for gestational age (weight)0.72 [0.18, 2.90]-1 study6,988117not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Assisted deliveries (forceps, vacuum, ...)1.26 [0.71, 2.24]-1 study46,049117not evaluable ROB-
Caesarean1.03 [0.70, 1.52]-1 study111,678117not evaluable ROB-
Maternal consequences (as a whole)1.09 [0.71, 1.67]-1 study311,181117not evaluable ROB-
Postpartum hemorrhage0.96 [0.42, 2.19]-1 study19,761117not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 1 min)1.53 [0.71, 3.30]-1 study14,890117not evaluable ROB-
Low Apgar score (< 7) (at 5 min)1.15 [0.07, 18.52]-1 study1,721117not evaluable ROB-
Neonatal death (< 28 days of life)3.17 [0.20, 50.97]-1 study627117not evaluable ROB-
Neonatal disorders (as a whole)1.52 [1.05, 2.19]-1 study161,467117not evaluable ROB2.41 [1.30; .]
Neonatal medical care1.46 [0.59, 3.60]-1 study8,571117not evaluable ROB-

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Child/Infant death (> 28 days of life)15.24 [0.94, 246.37]-1 study130117not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions0.87 [0.42, 1.80]-1 studynot evaluable ROB-

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