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Lofepramine
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Paternal exp. genotoxic window only (0–3 months preconception)
Paternal exposure: epigenetic window only (3–xxx months preconception)
Paternal exposure: genotoxic/epigenetic window (0–xxx months preconception)
Paternal exposure: other window
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Neuro-developmental disorders
ADHD (Attention deficit hyperactivity disorder): Diagnosis
Heuvelman, 2023
1
1.74
[
0.82
; 3.68]
-
296
not evaluable
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk
Heuvelman, 2023
1
1.74
[
0.82
; 3.68]
-
296
not evaluable
ASD (Autism spectrum disorder): Diagnosis
Heuvelman, 2023
1
2.52
[
1.23
; 5.17]
-
296
not evaluable
ASD (Autism spectrum disorder): Diagnosis/Risk
Heuvelman, 2023
1
2.52
[
1.23
; 5.17]
-
296
not evaluable
Cognitive developmental disorders/delay (> 6 years old)
Heuvelman, 2023
1
1.88
[
0.72
; 4.88]
-
296
not evaluable
Severe cognitive developmental delay (Mental retardation) (> 6 years old)
Heuvelman, 2023
1
1.88
[
0.72
; 4.88]
-
296
not evaluable
0.5
10.0
1.0