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Ethosuximide (All indications)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Samrén (Ethosuximide), 1999 Dean (Ethosuximide), 2002 Kaaja (Ethosuximide), 2003 Morrow (Ethosuximide) (Controls unexposed, sick), 2006 Bànhidy (Ethosuximide), 2011 Källén (Ethsuximide) (Controls unexposed, NOS) (Indications NOS), 2013 Tomson (Ethosuximide), 2018 Vajda (Ethosuximide) (Controls unexposed, sick), 2019
8
2.71
[
1.02
; 7.16]
49,640
58
not evaluable
Major congenital malformations
Samrén (Ethosuximide), 1999 Dean (Ethosuximide), 2002 Kaaja (Ethosuximide), 2003 Morrow (Ethosuximide) (Controls unexposed, sick), 2006 Bànhidy (Ethosuximide), 2011 Källén (Ethsuximide) (Controls unexposed, NOS) (Indications NOS), 2013 Tomson (Ethosuximide), 2018 Vajda (Ethosuximide) (Controls unexposed, sick), 2019
8
2.93
[
1.07
; 8.04]
49,634
58
not evaluable
Congenital heart defects
Morrow (Ethosuximide) (Controls exposed to Lamotrigine, sick), 2006
1
6.21
[
0.32
; 122.15]
4
12
not evaluable
Hypospadias
Morrow (Ethosuximide) (Controls exposed to Lamotrigine, sick), 2006
1
4.28
[
0.23
; 80.64]
6
12
not evaluable
Neural Tube Defects
Morrow (Ethosuximide) (Controls exposed to Lamotrigine, sick), 2006
1
18.71
[
0.72
; 484.16]
1
12
not evaluable
Digestive system anomalies
Morrow (Ethosuximide) (Controls exposed to Lamotrigine, sick), 2006
1
7.99
[
0.39
; 163.81]
3
12
not evaluable
Eye defects
Dean (Ethosuximide), 2002
1
5.33
[
0.29
; 97.49]
7
2
not evaluable
Limb defects
Morrow (Ethosuximide) (Controls exposed to Lamotrigine, sick), 2006
1
11.21
[
0.51
; 246.80]
2
12
not evaluable
Minor congenital malformations
Dean (Ethosuximide), 2002
1
2.20
[
0.19
; 25.52]
6
4
not evaluable
Oro-facial clefts
Morrow (Ethosuximide) (Controls exposed to Lamotrigine, sick), 2006
1
18.71
[
0.72
; 484.16]
1
12
not evaluable
Polydactyly
0
-
-
-
-
-
Growth parameters and prematurity
Low birth weight (< 2500g)
Kilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014
1
20.14
[
0.40
; 1017.27]
249
1
not evaluable
Preterm (< 37 weeks)
Kilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014
1
12.81
[
0.25
; 646.50]
383
1
not evaluable
Small for gestational age (weight)
Kilic (Ethosuximide) (Controls unexposed, sick) (Mixed indications), 2014
1
7.87
[
0.16
; 397.17]
594
1
not evaluable
Neonatal disorders
Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation
0
-
-
-
-
-
Neuro-developmental disorders
Neuro-developmental disorders (as a whole)
Dean (Ethosuximide), 2002
1
8.50
[
0.44
; 163.89]
5
2
not evaluable
0.0
100.0
1.0