Methotrexate (Pre-conception only)

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Matsui, 2003 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Dawson, 2014 Svirsky, 2017 Howren, 2020 51.41[0.59; 3.38]27,659214not evaluable Major congenital malformations Dawson, 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Svirsky, 2017 31.24[0.45; 3.42]27,658210not evaluable Minor congenital malformations Weber-Schoendorfer (Controls unexposed, disease free), 2014 11.96[0.73; 5.26]28113not evaluable Syndromes and chromosomal abnormalities Weber-Schoendorfer (Controls unexposed, disease free), 2014 11.26[0.15; 10.33]8114not evaluable Congenital heart defects Dawson, 2014 12.29[0.45; 11.83]11,0227not evaluable Growth parameters and prematurity Small for gestational age (weight) Svirsky, 2009 Howren, 2020 20.82[0.27; 2.47]645not evaluable Low birth weight (< 2500g) Svirsky, 2009 10.81[0.27; 2.37]1837not evaluable Preterm (< 37 weeks) Svirsky, 2009 10.82[0.19; 3.51]937not evaluable Intrauterine deaths Early intrauterine death (< 22 weeks) Svirsky, 2009 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Svirsky, 2017 30.55[0.18; 1.70]138274not evaluable Late intrauterine deaths (> 22 weeks) Svirsky, 2009 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Svirsky, 2017 31.74[0.27; 11.38]6274not evaluable Therapeutic terminations of pregnancy Svirsky, 2009 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Svirsky, 2017 31.42[0.51; 3.97]22274not evaluable Elective/induced termination of pregnancy Weber-Schoendorfer (Controls unexposed, disease free), 2014 12.40[1.06; 5.42]62136not evaluable Intrauterine deaths (as a whole or unspecified) Svirsky, 2009 Svirsky, 2017 20.37[0.09; 1.53]57138not evaluable0.020.01.0

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