meta
|
Preg
- medecines during pregnancy KB
Search
Omeprazole
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Lalkin (Controls unexposed NOS), 1998 Ruigomez (Controls unexposed NOS), 1999 Källén, 2001 Moretti, 2001 Diav-Citrin, 2005 Pasternak, 2010 Matok, 2012
7
1.05
[
0.89
; 1.24]
28,554
4,084
not evaluable
Major congenital malformations
Lalkin (Controls unexposed NOS), 1998 Moretti, 2001 Diav-Citrin, 2005 Pasternak, 2010 Matok, 2012
5
1.09
[
0.91
; 1.31]
28,472
3,082
not evaluable
Hypospadias
Källèn (Controls exposed to other treatment, sick), 1998 Ruigomez (Controls unexposed NOS), 1999 Pasternak, 2010 Lind, 2013
4
1.69
[
0.86
; 3.34]
1,539
2,211
not evaluable
Congenital hydronephrosis
Källèn (Controls exposed to other treatment, sick), 1998 Ruigomez (Controls unexposed NOS), 1999 Pasternak, 2010
3
0.90
[
0.35
; 2.30]
3
2,201
not evaluable
Cleft lip with or without cleft palate
Ruigomez (Controls unexposed NOS), 1999 Pasternak, 2010
2
0.82
[
0.15
; 4.34]
1
1,939
not evaluable
Cleft palate
Ruigomez (Controls unexposed NOS), 1999 Pasternak, 2010
2
1.42
[
0.26
; 7.72]
1
1,939
not evaluable
Club foot / Talipes equinovarus
Ruigomez (Controls unexposed NOS), 1999 Pasternak, 2010
2
1.05
[
0.36
; 3.07]
3
1,939
not evaluable
Congenital heart defects
Ruigomez (Controls unexposed NOS), 1999 Källén, 2003
2
1.39
[
0.45
; 4.34]
5,436
1,802
not evaluable
Down syndrom / Trisomy 21
Källèn (Controls exposed to other treatment, sick), 1998 Ruigomez (Controls unexposed NOS), 1999
2
4.24
[
0.35
; 50.76]
1
401
not evaluable
Microcephaly / Small head circumference for gestational age
Ruigomez (Controls unexposed NOS), 1999 Kerr, 2018
2
0.98
[
0.33
; 2.95]
138
108
not evaluable
Syndactyly
Ruigomez (Controls unexposed NOS), 1999 Pasternak, 2010
2
1.56
[
0.10
; 25.51]
-
1,939
not evaluable
Atrial septal defect
Källèn (Controls exposed to other treatment, sick), 1998 Pasternak, 2010
2
0.95
[
0.44
; 2.04]
-
2,062
not evaluable
Bilateral renal agenesis including Potter syndrome
Ruigomez (Controls unexposed NOS), 1999
1
3.79
[
0.15
; 93.41]
1
139
not evaluable
Cardiac septal defects
Ruigomez (Controls unexposed NOS), 1999
1
7.65
[
1.27
; 46.17]
5
139
not evaluable
Eye defects
Ruigomez (Controls unexposed NOS), 1999
1
2.27
[
0.11
; 47.54]
2
139
not evaluable
Genetic syndromes and microdeletions
Ruigomez (Controls unexposed NOS), 1999
1
1.26
[
0.07
; 23.52]
4
139
not evaluable
Limb defects
Ruigomez (Controls unexposed NOS), 1999
1
0.87
[
0.11
; 6.71]
14
139
not evaluable
Nervous system anomalies
Ruigomez (Controls unexposed NOS), 1999
1
2.27
[
0.11
; 47.54]
2
139
not evaluable
Polydactyly
Ruigomez (Controls unexposed NOS), 1999
1
1.26
[
0.07
; 23.52]
4
139
not evaluable
Ventricular septal defect
Källèn (Controls exposed to other treatment, sick), 1998 Pasternak, 2010
2
1.19
[
0.47
; 2.98]
3
2,062
not evaluable
Encephalocele
Källèn (Controls exposed to other treatment, sick), 1998
1
0.24
[
0.01
; 5.96]
1
262
not evaluable
Patent ductus arterious
Källèn (Controls exposed to other treatment, sick), 1998
1
2.19
[
0.09
; 54.15]
1
262
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Lalkin (Controls unexposed NOS), 1998 Ruigomez (Controls unexposed NOS), 1999 Diav-Citrin, 2005
3
1.28
[
0.91
; 1.78]
263
451
not evaluable
Low birth weight (< 2500g)
Källén, 2001 Choi, 2023
2
1.02
[
0.89
; 1.18]
104,260
3,372
not evaluable
Small for gestational age (weight)
Ruigomez (Controls unexposed NOS), 1999
1
0.55
[
0.03
; 9.17]
21
39
not evaluable
Maternal consequences
Caesarean
Lalkin (Controls unexposed NOS), 1998
1
0.97
[
0.48
; 1.98]
38
91
not evaluable
Preeclampsia
Van Gelder, 2022
1
1.10
[
0.48
; 2.51]
235
170
not evaluable
Neonatal disorders
Low Apgar score (< 7) (at 5 min)
0
-
-
-
-
-
Intrauterine deaths
Early intrauterine death (< 22 weeks)
Lalkin (Controls unexposed NOS), 1998 Diav-Citrin, 2005
2
1.37
[
0.89
; 2.11]
107
409
not evaluable
Late intrauterine deaths (> 22 weeks)
Ruigomez (Controls unexposed NOS), 1999 Diav-Citrin, 2005
2
1.62
[
0.15
; 17.97]
20
435
not evaluable
Therapeutic terminations of pregnancy
Lalkin (Controls unexposed NOS), 1998
1
1.21
[
0.36
; 4.09]
11
113
not evaluable
Ectopic pregnancy
0
-
-
-
-
-
Elective/induced termination of pregnancy
Diav-Citrin, 2005
1
3.00
[
1.72
; 5.23]
53
296
not evaluable
Perinatal death
Källén, 2001
1
1.66
[
0.70
; 3.96]
-
863
not evaluable
0.0
100.0
1.0
