Adalimumab

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Hyrich, 2006 Weber-Schoendorfer, 2015 Hoxha, 2017 Chambers (Controls, sick), 2019 De Lorenzo (Controls unexposed, sick), 2020 52.51[1.06; 5.97]62380not evaluable Major congenital malformations Hyrich, 2006 Weber-Schoendorfer, 2015 Hoxha, 2017 Chambers (Controls, sick), 2019 42.30[0.94; 5.64]62378not evaluable Microcephaly / Small head circumference for gestational age Chambers (Controls, sick), 2019 11.46[0.67; 3.17]39182not evaluable Minor congenital malformations Chambers (Controls, sick), 2019 10.59[0.31; 1.12]64173not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Hoxha, 2017 Chambers (Controls, sick), 2019 De Lorenzo (Controls unexposed, sick), 2020 31.17[0.40; 3.41]42220not evaluable Small for gestational age (weight) Chambers (Controls, sick), 2019 De Lorenzo (Controls unexposed, sick), 2020 20.80[0.40; 1.61]30208not evaluable Macrosomia (> 4000g) De Lorenzo (Controls unexposed, sick), 2020 121.00[0.30; 1469.95]-2not evaluable Small for gestational age (length) Chambers (Controls, sick), 2019 11.05[0.41; 2.68]19205not evaluable Maternal consequences Caesarean 0----- Maternal consequences (as a whole) Hoxha, 2017 19.00[0.29; 275.58]15not evaluable Neonatal disorders Neonatal infections Vinet (Unexposed controls, sick), 2018 Chambers (Controls, sick), 2019 20.96[0.41; 2.23]66337not evaluable Long term consequences Cancer (all kind) in children or adults Chambers (Controls, sick), 2019 10.48[0.01; 24.53]-229not evaluable Child/Infant head circumference abnormalities (> 1 year) Chambers (Controls, sick), 2019 12.10[0.42; 10.45]11161not evaluable Child/Infant weight abnormalities (> 1 year) Chambers (Controls, sick), 2019 11.17[0.54; 2.52]41168not evaluable Intrauterine deaths Early intrauterine death (< 22 weeks) Hyrich, 2006 Chambers (Controls, sick), 2019 22.39[0.78; 7.30]32260not evaluable Elective/induced termination of pregnancy Hyrich, 2006 Chambers (Controls, sick), 2019 21.95[0.15; 24.78]1260not evaluable Late intrauterine deaths (> 22 weeks) Chambers (Controls, sick), 2019 10.47[0.01; 23.62]-257not evaluable Intrauterine deaths (as a whole or unspecified) Hoxha, 2017 10.24[0.01; 5.76]35not evaluable Therapeutic terminations of pregnancy 0-----0.0100.01.0

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