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Temazepam
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
Congenital heart defects
Bonnot, 2003 Ban (Other indications) (Controls unexposed, sick), 2014
2
1.96
[
1.02
; 3.79]
2,687
381
not evaluable
Oro-facial clefts
Ban (Other indications) (Controls unexposed, sick), 2014
1
0.71
[
0.04
; 11.64]
35
379
not evaluable
Abdominal wall defects
Ban (Other indications) (Controls unexposed, sick), 2014
1
12.69
[
1.42
; 113.82]
5
379
not evaluable
All congenital malformations (majors, minors, majors and minors, or unspecified)
Ban (Other indications) (Controls unexposed, sick), 2014
1
1.04
[
0.47
; 2.31]
529
379
not evaluable
Chromosomal abnormalities
Ban (Other indications) (Controls unexposed, sick), 2014
1
0.78
[
0.05
; 12.74]
32
379
not evaluable
Digestive system anomalies
Ban (Other indications) (Controls unexposed, sick), 2014
1
1.45
[
0.09
; 24.12]
17
379
not evaluable
Ear, face and neck anomalies
Ban (Other indications) (Controls unexposed, sick), 2014
1
3.38
[
0.19
; 59.28]
7
379
not evaluable
Eye defects
Ban (Other indications) (Controls unexposed, sick), 2014
1
1.30
[
0.08
; 21.55]
19
379
not evaluable
Genital anomalies
Ban (Other indications) (Controls unexposed, sick), 2014
1
0.59
[
0.08
; 4.28]
86
379
not evaluable
Limb defects
Ban (Other indications) (Controls unexposed, sick), 2014
1
0.66
[
0.09
; 4.73]
78
379
not evaluable
Major congenital malformations
Ban (Other indications) (Controls unexposed, sick), 2014
1
1.04
[
0.47
; 2.31]
529
379
not evaluable
Nervous system anomalies
Ban (Other indications) (Controls unexposed, sick), 2014
1
3.28
[
0.78
; 13.75]
33
379
not evaluable
Respiratory system anomalies
Ban (Other indications) (Controls unexposed, sick), 2014
1
1.88
[
0.11
; 31.63]
13
379
not evaluable
Urinary malformations
Ban (Other indications) (Controls unexposed, sick), 2014
1
0.84
[
0.12
; 6.10]
61
379
not evaluable
Cleft lip with or without cleft palate
0
-
-
-
-
-
Cleft palate
0
-
-
-
-
-
Intrauterine deaths
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions
Sheehy, 2019
1
2.74
[
1.29
; 5.83]
27,149
29
not evaluable
0.0
100.0
1.0