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Clobazam (Psy and Mixed indications)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
Microcephaly / Small head circumference for gestational age
Christensen (Indications other than epilepsy), 2024
1
0.98
[
0.06
; 16.34]
133,324
17
not evaluable
All congenital malformations (majors, minors, majors and minors, or unspecified)
Noh (Indications NOS), 2022
1
1.18
[
0.73
; 1.91]
156,913
218
not evaluable
Congenital heart defects
Noh (Indications NOS), 2022
1
1.28
[
0.69
; 2.39]
83,595
218
not evaluable
Major congenital malformations
Noh (Indications NOS), 2022
1
1.18
[
0.73
; 1.91]
156,913
218
not evaluable
Growth parameters and prematurity
Small for gestational age (weight)
Kilic (Mixed indications), 2014
1
1.70
[
0.77
; 3.75]
65,123
30
not evaluable
Preterm (< 37 weeks)
Kilic (Mixed indications), 2014
1
3.30
[
2.05
; 5.32]
33,979
30
not evaluable
0.0
20.0
1.0
