Methotrexate (Post-conception)

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations All congenital malformations (majors, minors, majors and minors, or unspecified) Viktil (Controls unexposed NOS), 2012 Weber-Schoendorfer (Controls unexposed, disease free), 2014 Dawson, 2014 Cooper (Controls unexposed, sick), 2014 Howren, 2020 53.16[1.52; 6.54]32,664143not evaluable Major congenital malformations Viktil (Controls unexposed NOS), 2012 Dawson, 2014 Cooper (Controls unexposed, sick), 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 42.70[1.21; 6.02]32,664143not evaluable Congenital heart defects Dawson, 2014 Cooper (Controls unexposed, sick), 2014 24.80[0.57; 40.39]11,02330not evaluable Digestive system anomalies Cooper (Controls unexposed, sick), 2014 12.51[0.10; 63.53]123not evaluable Genital anomalies Cooper (Controls unexposed, sick), 2014 17.58[0.15; 391.43]-23not evaluable Limb defects Cooper (Controls unexposed, sick), 2014 17.58[0.15; 391.43]-23not evaluable Minor congenital malformations Weber-Schoendorfer (Controls unexposed, disease free), 2014 10.83[0.19; 3.57]25104not evaluable Nervous system anomalies Cooper (Controls unexposed, sick), 2014 17.58[0.15; 391.43]-23not evaluable Urinary malformations Cooper (Controls unexposed, sick), 2014 11.50[0.07; 32.20]223not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Cooper (Controls unexposed, sick), 2014 10.70[0.20; 2.53]3521not evaluable Small for gestational age (weight) Howren, 2020 11.73[0.35; 8.53]--not evaluable Neonatal disorders Neonatal disorders (as a whole) Cooper (Controls unexposed, sick), 2014 11.14[0.13; 9.77]821not evaluable Intrauterine deaths Late intrauterine deaths (> 22 weeks) Cooper (Controls unexposed, sick), 2014 Weber-Schoendorfer (Controls unexposed, disease free), 2014 25.05[1.21; 21.03]9211not evaluable Early intrauterine death (< 22 weeks) Weber-Schoendorfer (Controls unexposed, disease free), 2014 12.50[1.43; 4.38]118188not evaluable Elective/induced termination of pregnancy Weber-Schoendorfer (Controls unexposed, disease free), 2014 17.40[4.49; 12.18]98188not evaluable Therapeutic terminations of pregnancy Weber-Schoendorfer (Controls unexposed, disease free), 2014 14.23[1.78; 10.04]22188not evaluable0.0100.01.0

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