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Tofisopam
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Noh, 2022
1
1.05
[
0.94
; 1.18]
157,170
4,804
not evaluable
Congenital heart defects
Noh, 2022
1
1.09
[
0.93
; 1.28]
83,737
4,804
not evaluable
Major congenital malformations
Noh, 2022
1
1.05
[
0.94
; 1.18]
157,170
4,804
not evaluable
Ano-rectal atresia and stenosis
0
-
-
-
-
-
Atresia or stenosis of other parts of small intestine
0
-
-
-
-
-
Bilateral renal agenesis including Potter syndrome
0
-
-
-
-
-
Cleft lip with or without cleft palate
0
-
-
-
-
-
Cleft palate
0
-
-
-
-
-
Club foot / Talipes equinovarus
0
-
-
-
-
-
Ear malformations
0
-
-
-
-
-
Eye defects
0
-
-
-
-
-
Gastroschisis
0
-
-
-
-
-
Genital anomalies
0
-
-
-
-
-
Hydrocephaly
0
-
-
-
-
-
Hypospadias
0
-
-
-
-
-
Limb reduction defects (LRD)
0
-
-
-
-
-
Microcephaly / Small head circumference for gestational age
Eros, 2002
1
-
-
-
-
-
Neural Tube Defects
0
-
-
-
-
-
Oesophageal atresia with or without tracheo-oesophageal fistula
0
-
-
-
-
-
Polydactyly
0
-
-
-
-
-
0.8
5.0
1.0
