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Lorazepam
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
Ano-rectal atresia and stenosis
Bonnot, 2003 Tinker, 2019
2
3.67
[
0.65
; 20.64]
1,308
7
not evaluable
Cleft lip with or without cleft palate
Tinker, 2019
1
2.10
[
0.61
; 7.27]
3,086
11
not evaluable
Cleft palate
Tinker, 2019
1
1.04
[
0.13
; 8.49]
1,578
8
not evaluable
Congenital heart defects
Tinker, 2019 Noh, 2022
2
1.15
[
0.94
; 1.41]
95,880
2,489
not evaluable
All congenital malformations (majors, minors, majors and minors, or unspecified)
Noh, 2022
1
1.00
[
0.85
; 1.18]
157,050
2,468
not evaluable
Anophthalmos/micropthalmos
Tinker, 2019
1
7.19
[
0.88
; 58.68]
230
8
not evaluable
Anotia
Tinker, 2019
1
2.41
[
0.30
; 19.59]
685
8
not evaluable
Aortic valve atresia/stenosis
Tinker, 2019
1
3.23
[
0.40
; 26.34]
510
8
not evaluable
Atrial septal defect
Tinker, 2019
1
1.60
[
0.40
; 6.35]
3,025
10
not evaluable
Atrioventricular septal defect
Tinker, 2019
1
2.40
[
0.13
; 42.67]
369
7
not evaluable
Cardiac septal defects
Tinker, 2019
1
1.10
[
0.30
; 4.07]
4,673
10
not evaluable
Coarctation of aorta
Tinker, 2019
1
2.86
[
0.59
; 13.79]
1,153
9
not evaluable
Craniosynostosis
Tinker, 2019
1
2.09
[
0.43
; 10.06]
1,579
9
not evaluable
Diaphragmatic hernia
Tinker, 2019
1
1.02
[
0.06
; 18.16]
867
7
not evaluable
Gastroschisis
Tinker, 2019
1
3.50
[
0.90
; 13.66]
1,400
10
not evaluable
Hydrocephaly
Tinker, 2019
1
1.73
[
0.10
; 30.69]
513
7
not evaluable
Major congenital malformations
Noh, 2022
1
1.00
[
0.85
; 1.18]
157,050
2,468
not evaluable
Neural Tube Defects
Tinker, 2019
1
1.57
[
0.33
; 7.54]
2,105
9
not evaluable
Oesophageal atresia with or without tracheo-oesophageal fistula
Tinker, 2019
1
2.19
[
0.27
; 17.82]
753
8
not evaluable
Omphalocele
Tinker, 2019
1
2.04
[
0.11
; 36.28]
434
7
not evaluable
Oro-facial clefts
0
-
-
-
-
-
Pulmonary valve stenosis
Tinker, 2019
1
4.10
[
1.19
; 14.10]
1,532
11
not evaluable
Spina bifida
Tinker, 2019
1
0.71
[
0.04
; 12.68]
1,241
7
not evaluable
Tetralogy of Fallot
Tinker, 2019
1
2.76
[
0.57
; 13.29]
1,196
9
not evaluable
Transposition of the great vessels
Tinker, 2019
1
4.32
[
0.90
; 20.81]
765
9
not evaluable
Ventricular septal defect
Tinker, 2019
1
0.54
[
0.03
; 9.55]
1,648
7
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Calderon-Margalit, 2009 Meng a (Controls unexposed, sick), 2023
2
2.99
[
0.46
; 19.38]
263,495
11,093
not evaluable
Small for gestational age (weight)
Meng a (Controls unexposed, sick), 2023
1
1.18
[
1.11
; 1.25]
263,221
11,020
not evaluable
Intrauterine deaths
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions
Sheehy, 2019 Meng b, 2023
2
1.59
[
1.30
; 1.95]
27,149
588
not evaluable
Late intrauterine deaths (> 22 weeks) / Stillbirths
Meng a (Controls unexposed, sick), 2023
1
1.31
[
1.11
; 1.54]
30,858
11,182
not evaluable
0.0
100.0
1.0