Lorazepam

Table   Graphic  
individual studies
OutcomeTE95% CIn casesn exposedkPub. bias Congenital malformations Ano-rectal atresia and stenosis Bonnot, 2003 Tinker, 2019 23.67[0.65; 20.64]1,3087not evaluable Cleft lip with or without cleft palate Tinker, 2019 12.10[0.61; 7.27]3,08611not evaluable Cleft palate Tinker, 2019 11.04[0.13; 8.49]1,5788not evaluable Congenital heart defects Tinker, 2019 Noh, 2022 21.15[0.94; 1.41]95,8802,489not evaluable All congenital malformations (majors, minors, majors and minors, or unspecified) Noh, 2022 11.00[0.85; 1.18]157,0502,468not evaluable Anophthalmos/micropthalmos Tinker, 2019 17.19[0.88; 58.68]2308not evaluable Anotia Tinker, 2019 12.41[0.30; 19.59]6858not evaluable Aortic valve atresia/stenosis Tinker, 2019 13.23[0.40; 26.34]5108not evaluable Atrial septal defect Tinker, 2019 11.60[0.40; 6.35]3,02510not evaluable Atrioventricular septal defect Tinker, 2019 12.40[0.13; 42.67]3697not evaluable Cardiac septal defects Tinker, 2019 11.10[0.30; 4.07]4,67310not evaluable Coarctation of aorta Tinker, 2019 12.86[0.59; 13.79]1,1539not evaluable Craniosynostosis Tinker, 2019 12.09[0.43; 10.06]1,5799not evaluable Diaphragmatic hernia Tinker, 2019 11.02[0.06; 18.16]8677not evaluable Gastroschisis Tinker, 2019 13.50[0.90; 13.66]1,40010not evaluable Hydrocephaly Tinker, 2019 11.73[0.10; 30.69]5137not evaluable Major congenital malformations Noh, 2022 11.00[0.85; 1.18]157,0502,468not evaluable Neural Tube Defects Tinker, 2019 11.57[0.33; 7.54]2,1059not evaluable Oesophageal atresia with or without tracheo-oesophageal fistula Tinker, 2019 12.19[0.27; 17.82]7538not evaluable Omphalocele Tinker, 2019 12.04[0.11; 36.28]4347not evaluable Oro-facial clefts 0----- Pulmonary valve stenosis Tinker, 2019 14.10[1.19; 14.10]1,53211not evaluable Spina bifida Tinker, 2019 10.71[0.04; 12.68]1,2417not evaluable Tetralogy of Fallot Tinker, 2019 12.76[0.57; 13.29]1,1969not evaluable Transposition of the great vessels Tinker, 2019 14.32[0.90; 20.81]7659not evaluable Ventricular septal defect Tinker, 2019 10.54[0.03; 9.55]1,6487not evaluable Growth parameters and prematurity Preterm (< 37 weeks) Calderon-Margalit, 2009 Meng a (Controls unexposed, sick), 2023 22.99[0.46; 19.38]263,49511,093not evaluable Small for gestational age (weight) Meng a (Controls unexposed, sick), 2023 11.18[1.11; 1.25]263,22111,020not evaluable Intrauterine deaths Early intrauterine deaths (< 22 weeks) / Spontaneous abortions Sheehy, 2019 Meng b, 2023 21.59[1.30; 1.95]27,149588not evaluable Late intrauterine deaths (> 22 weeks) / Stillbirths Meng a (Controls unexposed, sick), 2023 11.31[1.11; 1.54]30,85811,182not evaluable0.0100.01.0