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Mebendazole
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
De Silva, 1999 Diav-Citrin, 2003 Acs, 2005 Torp-Pedersen (Controls unexposed, NOS), 2016
4
1.50
[
0.68
; 3.27]
45,490
1,528
not evaluable
Major congenital malformations
De Silva, 1999 Diav-Citrin, 2003 Acs, 2005 Torp-Pedersen (Controls unexposed, NOS), 2016
4
1.50
[
0.68
; 3.27]
45,490
1,528
not evaluable
Congenital heart defects
Acs, 2005
1
5.10
[
0.42
; 61.62]
4,479
3
not evaluable
Minor congenital malformations
Torp-Pedersen (Controls unexposed, NOS), 2016
1
0.80
[
0.48
; 1.34]
13,641
1,022
not evaluable
Digestive system anomalies
0
-
-
-
-
-
Genital anomalies
0
-
-
-
-
-
Hypospadias
Acs, 2005
1
8.60
[
0.79
; 93.86]
3,038
3
not evaluable
Limb defects
0
-
-
-
-
-
Nervous system anomalies
0
-
-
-
-
-
Polydactyly
Acs, 2005
1
13.50
[
1.20
; 151.44]
1,744
3
not evaluable
Growth parameters and prematurity
Small for gestational age (weight)
Torp-Pedersen (Controls unexposed, NOS), 2016
1
1.00
[
0.85
; 1.17]
70,203
2,567
not evaluable
Neonatal disorders
Neonatal death (< 28 days of life)
Torp-Pedersen (Controls unexposed, NOS), 2016
1
0.80
[
0.30
; 2.17]
2,060
2,567
not evaluable
Intrauterine deaths
Late intrauterine deaths (> 22 weeks)
Torp-Pedersen (Controls unexposed, NOS), 2016
1
0.90
[
0.39
; 2.06]
2,555
2,567
not evaluable
Early intrauterine death (< 22 weeks)
Diav-Citrin, 2003
1
1.25
[
0.65
; 2.42]
40
192
not evaluable
Ectopic pregnancy
0
-
-
-
-
-
Elective/induced termination of pregnancy
Diav-Citrin, 2003
1
8.15
[
2.40
; 27.73]
25
192
not evaluable
0.2
100.0
1.0