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Acetaminophen (Neuro-developmental outcomes)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Neuro-developmental disorders
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk
Liew, 2014 Ystrom or Gustavson (Ystrom - Population-Based), 2017 Tovo-Rodrigues, 2018 Chen, 2019 Sznajder, 2022 Ahlqvist (Population-Based), 2024
6
1.17
[
1.08
; 1.27]
149,447
280,000
serious
ADHD (Attention deficit hyperactivity disorder): Diagnosis
Liew, 2014 Ystrom or Gustavson (Ystrom - Population-Based), 2017 Chen, 2019 Ahlqvist (Population-Based), 2024
4
1.16
[
1.05
; 1.29]
148,170
278,039
not evaluable
Language disorders/delay
Liew a, 2016 Tronnes, 2020 Bertoldi_Pelotas, 2020 Tovo-Rodrigues, 2020 Woodbury a, 2024
5
1.00
[
0.99
; 1.01]
1,886
11,739
not evaluable
ADHD (Attention deficit hyperactivity disorder): Risk
Tovo-Rodrigues, 2018 Inoue, 2021 Sznajder, 2022
3
1.15
[
1.06
; 1.24]
3,069
23,631
not evaluable
ASD (Autism spectrum disorder): Diagnosis
Liew b, 2016 Ahlqvist (Population-Based), 2024
2
1.10
[
0.98
; 1.24]
69,611
222,096
not evaluable
ASD (Autism spectrum disorder): Diagnosis/Risk
Liew b, 2016 Ahlqvist (Population-Based), 2024
2
1.10
[
0.98
; 1.24]
69,611
222,096
not evaluable
Psychomotor developmental disorders/delay
Vlenterie, 2016 Tovo-Rodrigues, 2020 Bertoldi_Pelotas, 2020
3
0.99
[
0.89
; 1.10]
2,586
15,973
not evaluable
Cognitive developmental disorders/delay (< 3 years old)
Tovo-Rodrigues, 2020 Bertoldi_Pelotas, 2020
2
0.93
[
0.83
; 1.03]
-
2,470
not evaluable
Cognitive developmental disorders/delay (> 6 years old)
Ahlqvist (Population-Based), 2024
1
1.05
[
1.00
; 1.10]
24,554
185,909
not evaluable
Severe cognitive developmental delay (Mental retardation) (> 6 years old)
Ahlqvist (Population-Based), 2024
1
1.05
[
1.00
; 1.10]
24,554
185,909
not evaluable
ASD (Autism spectrum disorder): Risk
Alemany_DNBC, 2021
1
1.28
[
1.10
; 1.49]
729
34,584
not evaluable
Childhood autism (F84.0)
Liew b, 2016
1
1.10
[
0.89
; 1.36]
345
36,187
not evaluable
Cognitive developmental disorders/delay (3-6 years old)
Liew a, 2016
1
1.16
[
0.96
; 1.40]
-
881
not evaluable
0.8
5.0
1.0
