Benzodiazepines (Psy and mixed indications)


Study Exclusion reasons Rmk Reference
Gupta, 2012 inadequate or absent control group EXCLUDED: All children exposed to methadone, or buprenorphine or diamorphine or heroine or dihydrocodeine or diazepam => No adequate control group.

Gupta J Pediatr Ophthalmol Strabismus 2012; 49:58-63 10.3928/01913913-20110308-01

Wladimiroff, 1988 inadequate or absent control group EXCLUDED: There is no unexposed control group (or control group exposed to safe treatment). The cohort is only compared with data from the Eurocat Registry in the discussion, which is not an adequate control group.

Wladimiroff Ultrasound Med Biol 1988; 14:657-60 10.1016/0301-5629(88)90022-1

Crombie, 1975 inadequate or absent control group EXCLUDED: No unexposed control group. Only exposed pregnant women (chlordiazepoxide, diazepam and meprobamate), whose safety data are not sufficient to be a control group.

Crombie N Engl J Med 1975; 293:198-9 10.1056/nejm197507242930415

Jovin, 2023 inadequate or absent control group EXCLUDED: Case-series of neonatal abstinence syndrome (NAS) without adequate control group (no control group without exposure nor control group without NAS).

Jovin, V.M. Heroin Addict. Relat. Clin. Probl. 2023; 25:21-.

Damer, 2024 inadequate or absent control group EXCLUDED: All pregnant women exposed to psychotropics (atypical antipsychotic drugs, SSRI, Tricyclic Antidepressants (TCA), benzodiazepines, and different combinations) => No adequate control group.

Damer Gen Hosp Psychiatry 2024; 90:76-83 10.1016/j.genhosppsych.2024.06.015

Heintzelman, 2020 inadequate or absent control group EXCLUDED: All children exposed to opioids, cocaine, cannabis, barbiturates, benzodiazepines, amphetamines, methadone, or multiple drugs => No adequate control group.

Heintzelman, J. J.Cannabis Res. 2020; 2:871-. 10.1186/s42238-020-00047-9

St Clair - Alprazolam, 1992 inadequate or absent control group EXCLUDED: All pregnancies exposed to Alprazolam => No control group.

St Clair Obstet Gynecol 1992; 80:843-6

Van Wattum, 2023 inadequate or absent control group EXCLUDED: the prevalence of hyponatremia in women who used SSRI or SNRI during pregnancy compared to a control group of pregnant women who used benzodiazepines during pregnancy => No adequate control group.

van Wattum, J.J. Pharm. Weekbl. 2023; 158:17-.

Deck, 2015 other reason EXCLUDED: Because there is no mention of the antiepileptic drugs types except for malformed cases.

Deck Epilepsy Behav 2015; 51:166-9 10.1016/j.yebeh.2015.07.001

Meyer, 1973 not relevant exposure EXCLUDED: No data on benzodiazepines (and analysis in epileptic women).

Meyer Eur Neurol 1973; 10:179-90 10.1159/000114274

Levine, 2018 not relevant exposure EXCLUDED: Maternal prenatal benzodiazepines use was studied only as a covariate for the association between methadone exposure and poorer developmental outcomes.

Levine Early Hum Dev 2018; 116:68-75 10.1016/j.earlhumdev.2017.11.010

Sundbakk, 2025 not relevant exposure EXCLUDED: Analysis of 'Any benzodiazepine and/or z-hypnotic' as a whole without distinction of benzodiazepines.

Sundbakk Am J Epidemiol 2025; 194:73-84 10.1093/aje/kwae159

Pritham, 2012 not relevant exposure EXCLUDED: Benzodiazepines studied as a covariate for the Methadone Group Predicting Length of Stay (LOS).

Pritham J Obstet Gynecol Neonatal Nurs 2012; 41:180-190 10.1111/j.1552-6909.2011.01330.x

Wall-Wieler, 2020 not in pregnancy EXCLUDED: Exposure defined as women that fill any prescriptions for benzodiazepines in the 90 days before conception. => Not used during pregnancy (half-life: 1-3 days).

Wall-Wieler Hum Reprod 2020; 35:1685-1692 10.1093/humrep/deaa082

Niebyl, 1985 not about fetal exposure EXCLUDED: Urine were screened for Benzodiazepines, at an unknown time, very probably after pregnancy (case-control design) => exposure during pregnancy unknown.

Niebyl Cleft Palate J 1985; 22:20-8

McCarthy, 1999 not relevant outcome EXCLUDED: Analysis of birth weights as a continuous outcome (no dichotomous data available).

McCarthy Eur J Pediatr 1999; 158:748-9 10.1007/s004310051193

Oberlander, 2002 not relevant outcome EXCLUDED: non dichotomous outcomes (heart rate, respiratory power answer, ...).

Oberlander Pediatr Res 2002; 51:443-53 10.1203/00006450-200204000-00008

Zelner, 2015 not relevant outcome EXCLUDED: Analysis of poisonings in pregnancy managed by medical toxicologists at the bedside, but without fetal/neonatal/maternal safety data according to the treatment.

Zelner J Med Toxicol 2015; 11:301-8 10.1007/s13181-015-0467-y

Stika, 1990 data not abstractable EXCLUDED: Results not usable: means of behavioural score and 95% confidence intervals only available on a graphic and no other details in the text (only conclusion).

Stika Pharm Weekbl Sci 1990; 12:252-5 10.1007/BF01967827

Bonnot - BZDs, 2003 data not abstractable EXCLUDED: Raw data not sufficient to calculate OR (data for 'control' groups not available) and OR not provided by authors for Benzodiazepines as a whole.

Bonnot Encephale 2003; 29:553-9

Mattson, 2002 data not abstractable EXCLUDED: Not sufficient information provided by authors (BZD exposure was not related to a change in FSIQ score after controlling SES and NIC [adjusted means for BZD = 100.2, CONTROLS = 105.7; F(1,269) = 2.7, P = .099]. => Lack of confidence interval).

Mattson Neurotoxicol Teratol 2002; 24:359-67 10.1016/s0892-0362(02)00198-8

Brandlistuen, 2017 data not abstractable EXCLUDED: Raw data (linear regression coefficient) provided by authors did not allow to calculate an OR.

Brandlistuen PLoS One 2017; 12:e0181042 10.1371/journal.pone.0181042

Lee, 2024 data not abstractable EXCLUDED: data provided by authors (random forest rank and variable importance and random forest Shapley additive explanations (SHAP) values) not abstractable.

Lee PLoS One 2024; 19:e0296329 10.1371/journal.pone.0296329

Lee, 2021 data not abstractable EXCLUDED: results not extractable (authors provided 'Coefficients of determinants from logistic regression for each type of preterm birth' without confidence interval, odd ratio...).

Lee Diagnostics (Basel) 2021; 11: 10.3390/diagnostics11030555

Daugaard - Clonazepam (Indications NOS), 2020 repeat population groups, duplicate reports (most recent study included) Indications not specified. Overlapping between Bjork 2022 and Daugaard 2020 for Intellectual disabilities (2 outcomes), with more pregnancies in Bjork 2022 because longer study period and 5 countries => use of Bjork 2022 data.

Daugaard JAMA Netw Open 2020; 3:e2025570 10.1001/jamanetworkopen.2020.25570

Eros - 5 BZDs, 2002 repeat population groups, duplicate reports (most recent study included) EXCLUDED: Czeizel 2004, Czeizel 2003 and Eros 2002 used the same dataset to assess several benzodiazepines. To avoid redundancy of cases and controls, only the study with the most exposed cases was reported in the meta-analysis of class => Czeizel 2003.

Eros Eur J Obstet Gynecol Reprod Biol 2002; 101:147-54 10.1016/s0301-2115(01)00545-0

Rodriguez Pinilla, 1986 article unavailable EXCLUDED: Publication not found despite extensive searches.

Rodriguez Pinilla Med Clin (Barc) 1986; 87:741-3

Noya, 1981 article unavailable EXCLUDED: Publication not found despite extensive searches.

Noya Rev Cubana Hig Epidemiol 1981;19:200-10.

Ohtani, 2016 article unavailable EXCLUDED: Publication not found despite extensive searches.

Ohtani, H. J. Jpn. Epilepsy Soc. 2016; 33:663-. 10.3805/jjes.33.663

Pastuszak, 1996 article unavailable EXCLUDED: The full article was not found despite extensive searches, and data available in the abstract cannot be used ('no statistical difference in the rate of malformations, miscarriages, ...').

Pastuszak Can J Clin Pharmacol 1996;3:167-71.

Prandi, 2004 article unavailable EXCLUDED: Publication not found despite extensive searches.

Prandi, G. Ital. J. Pediatr. 2004; 30:113-.

Wikner, 2007 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of benzodiazepine (BZD) drugs or hypnotic benzodiazepine receptor agonists (HBRAs) as a whole, without distinction of BZD.

Wikner Pharmacoepidemiol Drug Saf 2007; 16:988-94 10.1002/pds.1391

Wikner, 2007 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of benzodiazepine (BZD) drugs or hypnotic benzodiazepine receptor agonists (HBRAs) as a whole, without distinction of BZD.

Wikner Pharmacoepidemiol Drug Saf 2007; 16:1203-10 10.1002/pds.1457

Sundbakk, 2022 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of 'Any benzodiazepine and/or z-hypnotic' as a whole without distinction of benzodiazepines.

Sundbakk JAMA Netw Open 2022; 5:e2246889 10.1001/jamanetworkopen.2022.46889

Odsbu, 2015 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of 'Any benzodiazepine and/or z-hypnotic' as a whole without distinction of benzodiazepines.

Odsbu Eur J Clin Pharmacol 2015; 71:283-91 10.1007/s00228-014-1797-4

Gardner, 1998 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Chlordiazepoxide analysed as a whole with nitrofurantoin and chlorpheniramine, as nitrosatable drug group.

Gardner Int J Epidemiol 1998; 27:64-7 10.1093/ije/27.1.64

Michielsen, 2014 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: analysis of medications (psychotropic drugs, antipsychotics, mood stabilizers, anxiolytics and hypnotics) as a whole, without distinction between treatments or subclass of treatments.

Michielsen, L.A. Neuropsychiatr. Dis. Treat. 2014; 10:13-. 10.2147/NDT.S53430

Ogunyemi, 2018 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: treatments analyses as a whole without distinction between treatments (SSRIs, benzodiazepines, other antidepressants (10.3%) and other medications including serotonin–norepinephrine reuptake inhibitors, antiepileptics and antipsychotics).

Ogunyemi, D. AJP Rep. 2018; 8:e146-. 10.1055/s-0038-1661379

Sundbakk, 2019 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of 'Any benzodiazepine and/or z-hypnotic' as a whole without distinction of benzodiazepines.

Sundbakk PLoS One 2019; 14:e0217830 10.1371/journal.pone.0217830

Sundbakk Nor. Epidemiol. 2018; 28:46-.

Sundbakk Pharmacoepidemiol. Drug Saf. 2017; 26:407-.

Hill, 1974 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of anticonvulsant group (N = 28) as a whole, without distinction between substances.

Hill Am J Dis Child 1974; 127:645-53 10.1001/archpedi.1974.02110240031002

Almgren, 2009 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Dichotomous analysis only performed for Any antiepileptics, or carbamazepine ou valproate (but not for clonazepam).

Almgren Seizure 2009; 18:672-5 10.1016/j.seizure.2009.09.002

Ali, 2014 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis ofI infants of mothers who substance misused (SM) during pregnancy as a whole, without distinction between substances (ecstasy, cocaine, cannabis, morphine, dihydrocodeine, heroin, and/or benzodiazepines).

Ali Ann Am Thorac Soc 2014; 11:933-8 10.1513/AnnalsATS.201403-124OC

Knobbe, 2023 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: The exposed group consisted of pregnant women exposed to BDZs and/or hypnotic benzodiazepine receptor agonists (HBRAs), without distinction between the 2 classes.

Knobbe Br J Clin Pharmacol 2023; 89:3005-3015 10.1111/bcp.15795

Sutter-Dallay, 2015 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of anxiolytics/hypnotics as a whole without distinction nor details on included substances.

Sutter-Dallay J Clin Psychiatry 2015; 76:967-73 10.4088/JCP.14m09070

Wikner, 2011 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of benzodiazepine (BZD) drugs or hypnotic benzodiazepine receptor agonists (HBRAs) as a whole, without distinction of BZD.

Wikner J Clin Psychopharmacol 2011; 31:356-9 10.1097/JCP.0b013e3182197055

Huitfeldt, 2020 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of 'Any benzodiazepine and/or z-hypnotic' as a whole without distinction of benzodiazepines.

Huitfeldt JAMA Netw Open 2020; 3:e205860 10.1001/jamanetworkopen.2020.5860

Kulaga, 2011 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: analysis of antiepileptics as a whole, without distinction between substances; and study performed only in women with epilepsy (indication not included in this meta-analysis).

Kulaga Seizure 2011; 20:667-72 10.1016/j.seizure.2011.06.012

Kulaga, S. Pharmacoepidemiol. Drug Saf. 2010; 19:S45-. 10.1002/pds.2019

Sundbakk, 2017 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: Analysis of 'Any benzodiazepine and/or z-hypnotic' as a whole without distinction of benzodiazepines.
Sutter-Dallay, 2010 Studies without separate analysis of the considered drug/class from other drugs/class EXCLUDED: analysis of psychotropic drugs as a whole, without distinction between substances.

Sutter-Dallay, A.-L. Ann. Med.-Psychol. 2010; 168:628-. 10.1016/j.amp.2010.07.007

Gerard, 2023 Review articles, letter to editor, editorial, comments EXCLUDED: Comment on the Bjork's 2022 study.

Gerard, E.E. Epilepsy Curr. 2023; 23:14-. 10.1177/15357597221130878

Game, 1999 Review articles, letter to editor, editorial, comments EXCLUDED: Comment on the Dolovich's meta-analysis (1998).

Game, E. Br. Med. J. 1999; 319:918-.

Jido, 2012 Indication not included in this meta-analysis EXCLUDED: Study performed in an acute pathology of pregnancy, i.e pre-eclampsia (indication not included in this meta-analysis).

Jido Afr Health Sci 2012; 12:148-52 10.4314/ahs.v12i2.11

Burja, 2006 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Burja, S. Wien. Klin. Wochenschr. 2006; 118:12-. 10.1007/s00508-006-0539-8

Samren, 1999 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Samren Ann Neurol 1999; 46:739-46

Czeizel, 2011 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Czeizel, A.E. Open Drug Saf. J. 2011; 2:9-. 10.2174/1876818001102010009

Dreier, 2021 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Dreier, J. Eur. J. Neurol. 2021; 28:106-. 10.1111/ene.14973

Ugwu, 2011 Indication not included in this meta-analysis EXCLUDED: Study performed only in women for an acute illness of pregnancy, i.e severe pre-eclampsia (indication not included in this meta-analysis).

Ugwu Niger J Clin Pract 2011; 14:418-21 10.4103/1119-3077.91747

Syam, 2016 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Syam, U.K. Ann. Indian Acad. Neurol. 2016; 19:318-. 10.4103/0972-2327.179974

Senel, 2014 Indication not included in this meta-analysis EXCLUDED: Study performed in an acute pathology of pregnancy, i.e premedication prior to caesarean section (indication not included in this meta-analysis).

Senel Braz J Anesthesiol 2014; 64:16-21 10.1016/j.bjane.2012.08.005

Suita, 1999 Indication not included in this meta-analysis EXCLUDED: Study performed in an acute pathology of pregnancy, i.e fetal anesthesia for perinatal stabilization in foetus with congenital diaphragmatic hernia (CDH) (indication not included in this meta-analysis).

Suita J Pediatr Surg 1999; 34:1652-7 10.1016/s0022-3468(99)90637-1

Meyers, 2017 Indication not included in this meta-analysis EXCLUDED: Study performed in an acute pathology of pregnancy, i.e fetal MRI scans (indication not included in this meta-analysis).

Meyers Fetal Diagn Ther 2017; 42:124-129 10.1159/000450978

Keni, 2020 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Keni Epilepsy Res 2020; 159:106250 10.1016/j.eplepsyres.2019.106250

Van de Velde, 2005 Indication not included in this meta-analysis EXCLUDED: Study performed only in women for an acute illness of pregnancy, i.e fetoscopic surgery (indication not included in this meta-analysis).

Van de Velde Anesth Analg 2005; 101:251-8, table of contents 10.1213/01.ANE.0000156566.62182.AB

Ravlo, 1989 Indication not included in this meta-analysis EXCLUDED: Study performed only in women for elective cesarean section anesthesia (indication not included in this meta-analysis).

Ravlo Anesth Analg 1989; 68:234-7

Guveli, 2017 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Guveli Clin Psychopharmacol Neurosci 2017; 15:19-27 10.9758/cpn.2017.15.1.19

Thomas, 2011 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Thomas, S.V. Birth Defects Res. Part A Clin. Mol. Teratol. 2011; 91:388-. 10.1002/bdra.20834

Canger, 1997 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Canger, R. Boll. Lega Ital. Epilessia 1997; 319:301-.

Thomas, 2008 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Thomas Pediatr Cardiol 2008; 29:604-8 10.1007/s00246-007-9161-4

Sami, 2008 Indication not included in this meta-analysis EXCLUDED: Study performed in an acute pathology of pregnancy, i.e eclampsia (indication not included in this meta-analysis).

Sami, R. JK Pract. 2008; 15:17-.

Thomas,, 2019 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Thomas, S. Neurology 2019; 92:87-.

Kazandi, 2010 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Kazandi, M. Turk Jinekoloji Obstet. Dernegi Derg. 2010; 7:212-.

Trivedi, 2018 Indication not included in this meta-analysis EXCLUDED: Study performed in women with epilepsy (indication not included in this meta-analysis).

Trivedi, M. Neurology 2018; 90:S277-.

Diaz-Romero, 1999 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Diaz-Romero Arch Med Res 1999; 30:186-9 10.1016/s0188-0128(99)00007-x

Thomas, 2014 Indication not included in this meta-analysis EXCLUDED: Study performed in women with epilepsy (indication not included in this meta-analysis).

Thomas, S.V. Ann. Indian Acad. Neurol. 2014; 17:S165-.

Vajda, 2012 Indication not included in this meta-analysis EXCLUDED: nearly all the pregnancies were in women with epilepsy (98.1%) => Study mainly performed in women with epilepsy (indication not included in this meta-analysis).

Vajda, F.J.E. Aust. New Zealand J. Obstet. Gynaecol. 2012; 52:49-. 10.1111/j.1479-828X.2011.01359.x

Galappatthy, 2018 Indication not included in this meta-analysis EXCLUDED: Study performed in women with epilepsy (indication not included in this meta-analysis).

Galappatthy BMC Pregnancy Childbirth 2018; 18:230 10.1186/s12884-018-1857-3

Dravet, 1992 Indication not included in this meta-analysis EXCLUDED: Study performed in women with epilepsy (indication not included in this meta-analysis).

Dravet Neurology 1992; 42:75-82

Thomas, 2017 Indication not included in this meta-analysis EXCLUDED: Study performed in women with epilepsy (indication not included in this meta-analysis).

Thomas Epilepsia 2017; 58:274-281 10.1111/epi.13632

Kalluru, 2021 Indication not included in this meta-analysis EXCLUDED: Study performed in a contexte of acute indication of pregnancy, i.e frozen embryo transfers (indication not included in this meta-analysis).

Kalluru, S. Fertil. Steril. 2021; 116:e179-. 10.1016/j.fertnstert.2021.07.492

Gidai, 2008 Indication not included in this meta-analysis EXCLUDED: Study performed in a particular context of pregnancy, i.e suicide attempt during pregnancy, with larges doses and acute intoxication with a potential strong impact of maternal health.

Gidai Toxicol Ind Health 2008; 24:29-39 10.1177/0748233708089019

Gidai, 2010 Indication not included in this meta-analysis EXCLUDED: Study performed in a particular context of pregnancy, i.e suicide attempt during pregnancy, with larges doses and acute intoxication with a potential strong impact of maternal health.

Gidai Pharmacoepidemiol Drug Saf 2010; 19:175-82 10.1002/pds.1885

Gidai, 2008 Indication not included in this meta-analysis EXCLUDED: Study performed in a particular context of pregnancy, i.e suicide attempt during pregnancy, with larges doses and acute intoxication with a potential strong impact of maternal health.

Gidai Toxicol Ind Health 2008; 24:41-51 10.1177/0748233708089018

Ditto, 1999 Indication not included in this meta-analysis EXCLUDED: Study performed in a particular indication, i.e Hyperemesis gravidarum (indication not included in this meta-analysis).

Ditto Gynecol Obstet Invest 1999; 48:232-6 10.1159/000010189

Dreier, 2021 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Dreier, J. Epilepsia 2021; 62:6-. 10.1111/epi.17079

Czeizel - Diazepam, 1999 Indication not included in this meta-analysis EXCLUDED: Study performed only in women without chronic somatic or mental disorders, and with threatened abortion or preterm labour (indication not included in this meta-analysis).

Czeizel Neurotoxicol Teratol 1999; 21:157-67 10.1016/s0892-0362(98)00043-9

Rallabhandi, 2023 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Rallabhandi, S. J. Cardiovasc. Dis. Res. 2023; 14:1424-. 10.48047/jcdr.2023.14.09.151

Trivedi, 2018 Indication not included in this meta-analysis EXCLUDED: Study performed in women with epilepsy (indication not included in this meta-analysis).

Trivedi Epilepsy Res 2018; 146:50-53 10.1016/j.eplepsyres.2018.07.016

Nakane, 1980 Indication not included in this meta-analysis EXCLUDED: Related to diazepam or chlordiazepoxide in epileptic women (indication excluded of the diazepam and chlordiazepoxide meta-analysis).

Nakane Epilepsia 1980; 21:663-80 10.1111/j.1528-1157.1980.tb04320.x

Wachman, 2018 Indication not included in this meta-analysis EXCLUDED: analysis of Benzodiazepines in pregnant women with opioid use disorder (OUD) (indication not included in this meta-analysis).

Wachman Drug Alcohol Depend 2018; 192:45-50 10.1016/j.drugalcdep.2018.07.024

Robert, 1986 Indication not included in this meta-analysis EXCLUDED: Related to diazepam in epileptic women (indication excluded of the diazepam meta-analysis) (Of note 1 exposed pregnancy).

Robert Eur Neurol 1986; 25:436-43 10.1159/000116048

Artama, 2011 Indication not included in this meta-analysis EXCLUSION: Study specifically conducted in women with epilepsy.

Artama Pharmacoepidemiol. Drug Saf. 2011; 20:S43-. 10.1002/pds.2206

Dreier, 2024 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Dreier JAMA Netw Open 2024; 7:e2356425 10.1001/jamanetworkopen.2023.56425

Czeizel, 1992 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Czeizel Eur J Epidemiol 1992; 8:122-7 10.1007/BF03334986

Kochen, 2011 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Kochen, S. Open Neurol. J. 2011; 5:63-. 10.2174/1874205X01105010063

Vajda, 2024 Indication not included in this meta-analysis EXCLUDED: Analysis of 'Any benzodiazepine and/or z-hypnotic' as a whole without distinction of benzodiazepines.

Vajda Epilepsy Res 2024; 200:107316 10.1016/j.eplepsyres.2024.107316

Brandao, 2024 Indication not included in this meta-analysis EXCLUDED: Study performed in a particular indication, i.e embryo transfer (indication not included in this meta-analysis).

Brandao J Assist Reprod Genet 2024; 41:2379-2383 10.1007/s10815-024-03206-6

Anithadevi, 2023 Indication not included in this meta-analysis EXCLUDED: Study performed only in women with epilepsy (indication not included in this meta-analysis).

Anithadevi, J. Res. J. Pharm., Biol. Chem. Sci. 2023; 14:425-. 10.33887/rjpbcs/2023.14.4.52