Tramadol (versus unexposed)

Study	Exclusion reasons	Rmk	Reference
Liu, 2015	not relevant exposure	EXCLUDED: not relevant exposure, tramadol not studied alone	Liu J Tradit Chin Med 2015; 35:620-5 10.1016/s0254-6272(15)30149-7
Patel, 2005	not relevant exposure	EXCLUDED: aim to assess the safety of labor epidural analgesia in subjects with pre-eclampsia. Tramadol not the exposure of interest, only the drug given in women who were not given epidural analgesia.	Patel J Obstet Gynaecol Res 2005; 31:291-5 10.1111/j.1447-0756.2005.00290.x
Viegas, 1993	not relevant outcome	EXCLUDED: no relevant safety outcomes (Heart rate, respiratory rate, pH, PO, and PCO, of the neonates and Apgar scores not developped)	Viegas Eur J Obstet Gynecol Reprod Biol 1993; 49:131-5 10.1016/0028-2243(93)90260-j
Jain, 2003	not relevant outcome	EXCLUDED: neonatal outcomes not extractable (weight in mean and apgar not shown). Other outcomes not relevant.	Jain Int J Gynaecol Obstet 2003; 83:19-27 10.1016/s0020-7292(03)00201-7
Fieni, 2000	not relevant outcome	EXCLUDED: Not relevant outcomes (Apgar score in mean).	Fieni Acta Biomed Ateneo Parmense 2000; 71 Suppl 1:397-400
Bitsch, 1980	not relevant outcome	EXCLUDED: not relevant outcomes (Apgar in mean and range). In German.	Bitsch Fortschr Med 1980; 98:632-4
Kainz, 1992	not relevant outcome	EXCLUDED: Not relevant outcomes (drowsiness, dry mouth, sweating, dizziness, nausea, vomiting...).	Kainz Z Geburtshilfe Perinatol ; 196:78-82
Husslein, 1987	not relevant outcome	EXCLUDED: Not relevant outcomes (nausea, vomiting, fatigue, drowsiness, somnolence). In German.	Husslein Z Geburtshilfe Perinatol ; 191:234-7
Long, 2003	not relevant outcome	EXCLUDED: Not relevant outcomes (Apgar score in mean and SD).	Long Chin Med J (Engl) 2003; 116:1752-5
Bredow, 1992	not relevant outcome	EXCLUDED: not relevant outcomes (Apgar >8). In German.	Bredow Zentralbl Gynakol 1992; 114:551-4
Tsai, 2001	data not abstractable	EXCLUDED: Apgar Scores of Newborns in Each Group in mean and SD. Not extractable.	Tsai Anesth Analg 2001; 93:1288-92 10.1097/00000539-200111000-00052
Elhakim, 2005	data not abstractable	EXCLUDED: Median (range) Apgar scores at 1 and 5 min. Not extractable.	Elhakim Br J Anaesth 2005; 95:811-5 10.1093/bja/aei260
Subedi, 2013	data not abstractable	EXCLUDED: neonatal outcomes not developped 'There were no statistically significant differences'. Data not extractable.	Subedi Int J Obstet Anesth 2013; 22:316-21 10.1016/j.ijoa.2013.05.009
Li, 1995	article unavailable	EXCLUDED: Because the article is unavailable.	Li Zhonghua Fu Chan Ke Za Zhi 1995; 30:345-8
Wen, 2021	Studies without separate analysis of the considered drug/class from other drugs/class	EXCLUDED: Tramadol use is too rare to be included in the analysis. No separate analysis of the considered drug.	Wen Drug Saf 2021; 44:1297-1309 10.1007/s40264-021-01115-6