Nefazodone - Medication and Pregnancy KB

Nefazodone

Exposed non-exposed, cohort studies

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Einarson 2009	Canada Not specified. prospective cohort	The Motherisk Program, a teratogenic information service.	Pregnant women who were exposed to Nefazodone in the first trimester of pregnancy. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed (general population or NOS) Pregnant women who were not exposed to antidepressants and who had called Motherisk for information regarding nonteratogenic drugs.	1st trimester	49 / 928
Einarson 2009	Canada Not specified. prospective cohort	The Motherisk Program, a teratogenic information service.	During the initial telephone contact, details of exposure and concurrent exposures are recorded on a standardized questionnaire.		1st trimester	49 / 928
Yaris 2005	Turkey 1999 - 2004 prospective cohort	Toxicology Information and Follow-up Service	Women who were exposed to Nefazodone during pregnancy for depression, anxiety, and psychotic disorders. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed (general population or NOS) Women who did not use any drug while pregnant.	during pregnancy (anytime or not specified)	2 / 248	Raw data for Intrauterine exitus not reported because the nb of cases in the unexposed group not clearly stated. Raw data for premature delivery not reported because the denominator is not clearly stated.
Yaris 2005	Turkey 1999 - 2004 prospective cohort	Toxicology Information and Follow-up Service	Data surveyed by the interviews.		during pregnancy (anytime or not specified)	2 / 248

Case-control studies

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Anderson 2020	USA 1997 - 2011 case control	The National Birth Defects Prevention Study (NBDPS), a US population-based, multisite case-control study.	The case infants were infants born alive or died at 20 SG or more and who had received a diagnosis of at least one selected birth defect.	The controls were live-born infants with no major birth defects who were randomly selected from hospital or state birth-certificate records from the same geographic areas.	Information on exposure to SSRIs and other potential risk factors during pregnancy were collected by standardized telephone interviews with mothers of case and control infants, conducted 6 weeks to 24 months after the EDD.	1st trimester	30630 / 11478	'Infants with recognized or strongly suspected chromosomal abnormalities or single-gene conditions were excluded from the study.'
Anderson 2020	USA 1997 - 2011 case control		Case infants were ascertained through population-based birth-defects surveillance systems in 10 U.S. states. Controls were selected randomly from the same geographic areas. Clinical data were abstracted from medical records and classified by clinician geneticists and other clinicians.			1st trimester	30630 / 11478

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;

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