Methsuximide (Epilepsy = All indications)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)
Battino (Methsuximide) (Epilepsy) 2024	Worldwide (47 countries) 1999 - 2022 prospective cohort	The International Registry of Antiepileptic Drugs and Pregnancy (EURAP).	Pregnant women with epilepsy exposed to Methsuximide monotherapy at the time of conception.	exposed to other treatment, sick Pregnant women with epilepsy exposed to lamotrigine monotherapy at the time of conception.	early pregnancy	1 / 3584
Battino (Methsuximide) (Epilepsy) 2024	Worldwide (47 countries) 1999 - 2022 prospective cohort		Reporting physicians collected information on drug therapy after each trimester.		early pregnancy	1 / 3584
Samrén (Methsuximide) 1999	Netherlands 1972 - 1994 retrospective cohort	28 hospitals in four provinces of the Netherlands and National Perinatal Data Base LVR.	Children born to mothers with epilepsy and using methsuximide monotherapy at least during the first trimester of pregnancy	unexposed, disease free Children born to nonepileptic nonexposed women.	at least 1st trimester	1 / 2000
Samrén (Methsuximide) 1999	Netherlands 1972 - 1994 retrospective cohort		Data were collected from medical records and include medication. The prescribed dose of thedrugs was also retrieved from obstetric files.		at least 1st trimester	1 / 2000

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;