| Study | Country Study period Study design |
Data source | Exposure definition | Non-exposure definition | Exposition period | Sample size (exposed/unexposed) Or (case / control) |
Remarks | Risk of bias |
|---|
| Study | Country Study period Study design |
Data source | Case | Control | Exposition | Exposition period | Sample size (exposed/unexposed) Or (case / control) |
Remarks | Risk of bias |
|---|---|---|---|---|---|---|---|---|---|
|
Fejzo 2015 |
USA 2007 - 2011 case control |
A part of a larger investigation evaluating the 44 genetics and epidemiology of Hyperemesis gravidarum (HG) | Children exposed to hyperemesis gravidarum (HG) with neurodevelopmental delay. | Children exposed to hyperemesis gravidarum (HG) with a good outcome. | Participants were asked to submit their medical records and complete an online survey regarding treatment. | during pregnancy (anytime or not specified) | 138 / 174 | Main analysis: case control related to the impact of the HG illness (treated or not) on child outcomes. Then impact of 37 medications/treatments (1st and/or 2nd trimester) on child outcome was investigated (none was significantly associated with delay). | |
| Participants were asked to submit their medical records and complete an online survey regarding outcomes. A follow-up survey was administered on the diagnosis of childhood emotional, behavioral, and learning disorders. | |||||||||
|
Fejzo 2013 |
USA 2007 - 2011 case control |
A part of a larger investigation evaluating the genetics and epidemiology of Hyperemesis gravidarum (HG). | Pregnant women with hyperemesis gravidarum (HG) who have negative outcomes (birth weight less than 10%, perinatal mortality, and/or preterm birth (<37 weeks)). | Pregnant women with hyperemesis gravidarum (HG) who have positive outcomes. | Participants were asked to submit their medical records and complete an online surveyregarding treatment. The majority of participants, both cases and controls, joined the study and began the survey during their pregnancies. | during pregnancy (anytime or not specified) | 43 / 211 | Comparison of use of various medications/treatments in the two groups (43 HG participants with an adverse outcome compared to 211 HG participants with a good outcome). | |
| Participants were asked to submit their medical records and complete an online surveyregarding outcomes. The majority of participants, both cases and controls, were automatically prompted to complete the survey on outcome following their due date. | |||||||||
Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;
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