Bendroflumethiazide (versus unexposed)

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Leather 1968	United Kingdom Not specified. randomized controlled trial	Department of Clinical research, Plymouth general hospital, United Kingdom.	Pregnant patients with early hypertension (before 20 gestational weeks) randomly allocated to treatment group, i.e bendrofluazide 5-10 mg daily with potassium supplements and methyldopa 0-5-2g daily in divided doses.	unexposed, sick Pregnant patients with early hypertension (before 20 gestational weeks) randomly allocated to control group.	during pregnancy (anytime or not specified)	23 / 24	Data related to chronic hypertension were reported here.
Leather 1968	United Kingdom Not specified. randomized controlled trial		On entry to the trial patients were allocated at random to control or treatment groups.		during pregnancy (anytime or not specified)	23 / 24	Data related to chronic hypertension were reported here.

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;