Metronidazole (local route only) - Medication and Pregnancy KB

Metronidazole (local route only)

Exposed non-exposed, cohort studies

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Empty. There are no case-control studies available for this drug.

Case-control studies

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Kazy - Metronidazole 2005	Hungary 1980 - 1996 case control	The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA).	Cases with congenital abnormalities (CAs) were selected from the Hungarian Congenital Abnormality Registry.	Controls were extracted from from the National Birth Registry of the Central Statistical Office.	The exposure data were obtained: (i) prospectively through antenatal care logbooks and other medical records; (ii) retrospectively by questionnaires completed by mothers; and (iii) by the help of regional nurses who visited and questioned all nonrespondent case and 200 control mothers.	1st trimester, during pregnancy (anytime or not specified)	22843 / 38151	The Hungarian Case–Control Surveillance of Congenital Abnormalities was used 2 times to assess vaginal Metronidazole (Kazy 2005a; b): to avoid redundancy of cases and controls, only 1 was used => metronidazole alone (rather than in association).
Kazy - Metronidazole 2005	Hungary 1980 - 1996 case control		Not specified.			1st trimester, during pregnancy (anytime or not specified)	22843 / 38151
Zarante 2009	Colombia 2001- 2006 case control	The Institute of Human Genetics of the Pontificia Universidad Javeriana, an active member of the Latin-American Collaborative Study of Congenital Malformations (ECLAMC) which is an international registry of congenital malformations .	All newborns and stillborns of weight >500 g that presented only one craniofacial malformation, not associated with any other congenital condition.	The next non-malformed same sex child born in the same hospital.	Information collected in 10 Colombian hospitals (NOS).	during pregnancy (anytime or not specified)	374 / 728
Zarante 2009	Colombia 2001- 2006 case control		Information collected in 10 Colombian hospitals (NOS).		Information collected in 10 Colombian hospitals (NOS).	during pregnancy (anytime or not specified)	374 / 728

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;

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