Perindopril

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Colvin 2010	Australia 2002 - 2005 retrospective cohort (claims database)	Linkage between administrative records of medicines dispensed in pregnancy (Pharmaceutical Benefits Scheme (PBS) and health administrative data.	Perindopril erbumine dispensed from 14 days after the last menstrual period (LMP) to the end of first trimester or to the end of the pregnancy event. (This is a subgroup of exposure among the whole exposed group considered in the study).	unexposed (general population or NOS) All other births (those births to women dispensed a Pharmaceutical Benefits Scheme (PBS) medicine or not).	1st trimester	32 / 106042	Category D or X medicines also studied. Total nb of unexposed: 106042=106074-32. Birth defect: structural or functional abnormality. Most minor defects are not recorded in the BDR. Of all cases, about 90% have at least one major birth defect.
Colvin 2010			The national Pharmaceutical Benefits Scheme, with around 80% of prescriptions dispensed in Australia.		1st trimester	32 / 106042

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;