Lormetazepam

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Kitchin 2022	Spain 2002 - 2015 case control	The Spanish database BIFAP (Base de Datos para la Investigacion Farmacoepidemiologica en Atencion Primaria, Database for Pharmacoepidemiological Research in Primary Care).	Pregnant woman suffering a miscarriage.	Pregnant woman randomly selected from the whole cohort among women who were still at risk within follow-up, by risk-set sampling and individually matched to cases.	Database for Pharmacoepidemiological Research in Primary Care, a computerized medical longitudinal population database of electronic medical records from 10.153 primary care practitioners and pediatricians distributed on nine Autonomous Regions (out of 17), which contains prescriptions.	1st trimester	18070 / 54209	Authors provided 2 exposure definitions: Use in both periods (continuers) and Use only during pregnancy (new users) => use of data for 'Use in both periods (continuers)', to decrease misclassification bais (exposure occurred before outcome).
Kitchin 2022	Spain 2002 - 2015 case control		Database for Pharmacoepidemiological Research in Primary Care, a computerized medical longitudinal population database of electronic medical records from 10.153 primary care practitioners and pediatricians, which contains medical diagnoses, medical visits, hospital admissions.			1st trimester	18070 / 54209

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;