Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

Oro-facial clefts

id	Study   Auto Howley - BDS study, 2021Howley - NBDPS study, 2021Huybrechts (Controls unexposed, sick), 2021	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13680 R53160	Howley - BDS study, 2021	Any oral cleft	3 months (or more) before pregnancy or during pregnancy excluded	case control	unexposed (general population or NOS)	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	1.22 [0.25;3.56] excluded (exposition period)	3/-   -/-	-	-		ref
S13681 R53168	Howley - NBDPS study, 2021	Any oral cleft	3 months (or more) before pregnancy or during pregnancy excluded	case control	unexposed (general population or NOS)	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	1.87 [0.69;4.07] excluded (exposition period)	6/-   -/-	-	-		ref
					Total	0 studies	NaN [NaN;NaN]		0	0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis