Hydroxychloroquine (All indications except Antiphospholipid Syndrom) - Medication and Pregnancy KB

Hydroxychloroquine (All indications except Antiphospholipid Syndrom)

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S13645 R52902	Bérard, 2021	Major congenital malformations	1st trimester	nested case control	unexposed (general population or NOS)	Adjustment: Yes Indication HCQ: Any or not specified	1.15 [0.65;2.04]	16/103 23,975/230,972	23,991	103		ref
S13680 R53164	Howley - BDS study, 2021	Major birth defects	early pregnancy	case control	unexposed (general population or NOS)	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	0.62 [0.23;1.62] ^C	10/17 29,828/42,689	29,838	17		ref
S13681 R53172	Howley - NBDPS study, 2021	Major birth defects	early pregnancy	case control	unexposed (general population or NOS)	Adjustment: No Indication HCQ: Rheumatic diseases as a whole (Systemic lupus erythematosus, Rheumatoid arthritis, Sjogren's syndrome...)	1.29 [0.43;3.93] ^C	14/18 31,454/43,064	31,468	18		ref
					Total	3 studies	1.02 [0.65;1.61]		85,297	138
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Umbrella review (other published meta-analyses)